{"product_id":"biolegend-163504","title":"Biolegend, 163504, PE anti-mouse IFN-γ Antibody, 100μg","description":"\u003cp\u003eIFN-γ is a potent multifunctional cytokine which is secreted primarily by activated NK cells and T cells. Originally characterized based on anti-viral activities, IFN-γ also exerts anti-proliferative, immunoregulatory, and proinflammatory activities. IFN-γ can upregulate MHC class I and II antigen expression by antigen-presenting cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Wang R, et al. 2023. iScience. 26:105954. PubMed Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed Yi H, et al. 2021. Front Immunol. 12:719189. PubMed\u003cbr\u003e\nRRID: AB_2890730 (BioLegend Cat. No. 163503) AB_2890730 (BioLegend Cat. No. 163504)\u003cbr\u003e\nStructure: Cytokine; dimer; 40-80 kD (Mammalian)\u003cbr\u003e\nDistribution: Tregs\u003cbr\u003e\nFunction: Upregulated by IL-2, FGF-basic, EGF; downregulated by 1-α-25-Dihydroxy vitamin D3, dexamethasone\u003cbr\u003e\nLigand\/Receptor: Receptors: IFN-γRα (CDw119) dimerized with IFN-γRβ (AF-1)\u003cbr\u003e\nAntigen References: 1. Zaidi et al. 2011, Clin Cancer Res,17(19):6118-24 2. Castro et al. 2018, Front Immunol, 9:847 3. Alspach et al. 2019, Cold Spring Harb Perspect Biol, 11(3):a028480\u003cbr\u003e\nGene ID: 15978\u003cbr\u003e\nUniProt: View information about IFN-gamma on UniProt.org\u003cbr\u003e\nClone: W18272D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interferon-γ, Immune interferon, Type II interferon, T cell interferon, Macrophage-activating factor (MAF)\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864084435113,"sku":"163504","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-163504","provider":"Iright","version":"1.0","type":"link"}