{"product_id":"biolegend-168002","title":"Biolegend, 168002, Purified anti-mouse Siglec-G Antibody, 100μg","description":"\u003cp\u003eSiglec-G is a member of the CD33-related Siglec (sialic acid–binding, immunoglobulin-like lectin) family. Siglec-G is the orthologue of human Siglec-10. It is a 110-120 kD, 688 amino acid type I transmembrane protein and contains five extracellular immunoglobulin domains and an intracellular region with three conserved tyrosine-based motifs. It is an inhibitory receptor that is expressed in a B cell–restricted way, with particularly high expression in Pre-B and B1a cells. Upon stimulation with an antigen, Siglec-G is recruited to IgM, which is further phosphorylated inhibiting IgM-induced Ca2+ signaling and NFATc1 expression.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-P - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone W20144F cannot block the binding of clone SH1.\u003cbr\u003e\nRRID: AB_3698941 (BioLegend Cat. No. 168002)\u003cbr\u003e\nStructure: Type I transmembrane protein that contains five extracellular immunoglobulin domains and an intracellular region with three conserved tyrosine-based motifs.\u003cbr\u003e\nDistribution: B cells\u003cbr\u003e\nFunction: Inhibitis IgM-induced Ca2+ signaling and NFATc1 expression\u003cbr\u003e\nLigand\/Receptor: Lectin\u003cbr\u003e\nGene ID: 243958\u003cbr\u003e\nUniProt: View information about Siglec-G on UniProt.org\u003cbr\u003e\nClone: W20144F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Siglec-G\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866422431913,"sku":"168002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-168002","provider":"Iright","version":"1.0","type":"link"}