{"product_id":"biolegend-205608","title":"Biolegend, 205608, FITC anti-rat CD161 Antibody, 100μg","description":"\u003cp\u003eCD161 is a 30 kD type II transmembrane C-type lectin, expressed as a homodimer. Rat NKR-P1 receptors are primarily expressed on NK cells, a subset of T cells, dendritic cells, and activated monocytes. There are three different types of NKR-P in rat, namely NKR-P1a, NKR-P1b, and NKR-P1c. NKR-P1a does not contain an ITIM structure and is an activating receptor, while NKR-P1b contains an ITIM and displays inhibitory function. LLT-1 (ligand lectin like transcript 1) is the ligand, while KLR (killer cell lectin like) functions as a receptor.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: LEW rat splenic NK cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: 3.2.3 recognizes a common epitope of NKR-1P1a (CD161a) and NKR-P1b (CD161b).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Chambers W, et al. 1989. J. Exp. Med. 169:1373. (FC)\u003cbr\u003e\nProduct Citations: Manganaro JE, et al. 2024. Sci Rep. 23861:14. PubMed Dolen Y, et al. 2015. Cell Immunol. 295:29. PubMed Jo BG, et al. 2020. Mol Med. 26:119. PubMed\u003cbr\u003e\nRRID: AB_2564547 (BioLegend Cat. No. 205608)\u003cbr\u003e\nStructure: Type II transmembrane C-type lectin, 30 kD.\u003cbr\u003e\nDistribution: NK cells, subset of T cells, dendritic cells, activated monocytes.\u003cbr\u003e\nFunction: NKR-P1a is a NK cell-activating receptor; NKR-P1b is a NK cell-inhibitory receptor.\u003cbr\u003e\nLigand\/Receptor: LLT1-ligand lectin like transcript 1; KLR-killer cell lectin like receptor.\u003cbr\u003e\nCell Type: Dendritic cells, Monocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Chambers WH, et al. 1989. J. Exp. Med. 169:1373. 2. Brink M, et al. 1990. J. Exp. Med. 171:197. 3. Li J, et al. 2003. Int. Immunol. 15:411.\u003cbr\u003e\nGene ID: 362443\u003cbr\u003e\nUniProt: View information about CD161 on UniProt.org\u003cbr\u003e\nClone: 3.2.3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: NKR-P1, CD161a\/CD161b, NKR-P1a\/KLRB1a\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862332461225,"sku":"205608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-205608","provider":"Iright","version":"1.0","type":"link"}