{"product_id":"biolegend-250505","title":"Biolegend, 250505, PE anti-rat CD38 Antibody, 50μg","description":"\u003cp\u003eCD38 is a 45 kD type II transmembrane ADP-ribosyl cyclase expressed on early hematopoietic precursors and leukocytes, hepatic stellate cells, astrocytes and epithelial cells. CD38 expression can be upregulated upon cell activation. CD38 catalyzes the production of cyclic APD ribose, which is important in Ca 2+ release. CD38 induces production of proinflammatory cytokines and proliferation. The ligand for CD38 is CD31. Impairment in CD38 expression is associated with immunological and behavioral disorders.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunohistochemistry1 and Western blotting1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): March S, et al. 2007. Am. J. Pathol. 170:176. (IHC, WB)\u003cbr\u003e\nProduct Citations: Follin B, et al. 2021. Int J Mol Sci. 22: . PubMed Ding X, et al. 2020. Kidney360. 1:106. PubMed\u003cbr\u003e\nRRID: AB_2563069 (BioLegend Cat. No. 250505)\u003cbr\u003e\nStructure: CD38 is a 45 kD type II transmembrane protein.\u003cbr\u003e\nDistribution: Early hematopoietic precursors and leukocytes, astrocytes, hepatic stellate cells, and epithelial cells; upregulated upon activation.\u003cbr\u003e\nFunction: CD38 catalyzes the production of cyclic APD ribose, which is important in Ca2+ release. CD38 induces production of proinflammatory cytokines and proliferation.\u003cbr\u003e\nLigand\/Receptor: CD31, hyaluronic acid\u003cbr\u003e\nCell Type: Astrocytes, B cells, Dendritic cells, Epithelial cells, Leukocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, MHC Antigens\u003cbr\u003e\nAntigen References: 1. Ota H, et al. 2012. Life Sci. 90:206. 2. Masuda W, et al. 2011. Arch. Biochem. Biophys. 2:131. 3. Khoo KM, et al. 1998. Biochem. Mol. Biol. Int. 44:841. 4. Prasad GS, et al. 1996. Nat. Struct. Biol. 3:957.\u003cbr\u003e\nGene ID: 25668\u003cbr\u003e\nUniProt: View information about CD38 on UniProt.org\u003cbr\u003e\nClone: 14.27\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T10 , ADP-ribosyl cyclase\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860802425001,"sku":"250505","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-250505","provider":"Iright","version":"1.0","type":"link"}