{"product_id":"biolegend-250705","title":"Biolegend, 250705, PE anti-rat NKG2A\/C\/E Antibody, 25μg","description":"\u003cp\u003eThe NKG2 molecules are a family of lectin-like receptors that form heterodimers with CD94. NKG2\/CD94 heterodimer are primarily expressed on NK cells, and a subset of CD8 + T cells. Studies of CD94\/NKG2 heterodimers on NK cells have demonstrated that the NKG2 components transduce signals after ligand binding.  NKG2A transduces inhibitory signals, while NKG2C and NKG2E transduce activating signals.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant rat NKG2A-Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Sasther PC, et al, 2011, J Immunol, 187:6365\u003cbr\u003e\nRRID: AB_2728230 (BioLegend Cat. No. 250706)\u003cbr\u003e\nStructure: Type II transmembrane protein\u003cbr\u003e\nDistribution: NK cells, a subset of CD8+ T-lymphocytes.\u003cbr\u003e\nFunction: Signal transduction, Receptor for non-classical MHC Class I molecules\u003cbr\u003e\nInteraction: DAP10, DAP12, CD94\u003cbr\u003e\nLigand\/Receptor: Non-classical MHC Class I glycoproteins\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nAntigen References: Berg SF, et al. 1998. Eur J Immunol, 28:444. Vance RE, et al. 1999. J Exp Med. 190(12). Vance RE, et al. 1998. J Exp Med. 188(10). Flornes LM, et al. 2010, Immunogenetics, 62:521 Dissen E, et al. 2008. Semin Immunol. 20:369\u003cbr\u003e\nGene ID: 2968329684500338\u003cbr\u003e\nUniProt: View information about NKG2A on UniProt.org\u003cbr\u003e\nClone: WEN28\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: KLRC1, Killer Cell Lectin Like Receptor C1, KLRC2, Killer Cell Lectin Like Receptor C2, KLRC3, Killer Cell Lectin Like Receptor C3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864089448617,"sku":"250705","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-250705","provider":"Iright","version":"1.0","type":"link"}