{"product_id":"biolegend-260358","title":"Biolegend, 260358, GMP APC anti-human CD41 Antibody, 100tests","description":"\u003cp\u003eCD41 is a 125\/25 kD α subunit of the gpIIb\/IIIa (CD41\/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41\/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin.\u003cbr\u003e\n100tests\u003cbr\u003e\nReactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Capuchin Monkey, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w\/v) BSA (origin USA) and a stabilizer\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 25 µg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and blocking of platelet aggregation2. The HIP8 antibody has been reported to block the activation of platelets by various stimuli, including collagen, and ADP.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. McCarty OJT, et al. 2000. Blood 96:1789. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) Zhi L et al. 2013. PLoS One. 8:e79869. (IHC)\u003cbr\u003e\nDisclaimer: GMP RUO Flow Cytometry Antibodies. BioLegend GMP RUO fluorophore conjugated antibodies are manufactured in a dedicated GMP facility and compliant with ISO 13485:2016. For research use only. Not for use in diagnostic or therapeutic procedures. Our processes include: Batch-to-batch consistency Material traceability Documented procedures Documented employee training Equipment maintenance and monitoring records Lot-specific certificates of analysis Quality audits per ISO 13485:2016 QA review of released products\u003cbr\u003e\nStructure: Integrin family, α subunit of CD41\/CD61 (GPIIb-IIIa) complex, 125\/22 kD\u003cbr\u003e\nDistribution: Platelets, megakaryocytes\u003cbr\u003e\nFunction: Platelet aggregation, platelet attachment to extracellular matrix\u003cbr\u003e\nLigand\/Receptor: Fibrinogen, fibronectin, von Willebrand factor, thrombin\u003cbr\u003e\nCell Type: Megakaryocytes, Platelets\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Denzin L, et al. 1996. J. Exp. Med. 184:2153. 2. Denzin L, et al. 1995. Cell 82:155. 3. Riberdy J, et al. 1994. J. Cell Biol. 125:1225.\u003cbr\u003e\nGene ID: 3674\u003cbr\u003e\nUniProt: View information about CD41 on UniProt.org\u003cbr\u003e\nClone: HIP8\u003cbr\u003e\nWorkshop: IV P38\u003cbr\u003e\nOther Names: gpIIb, CD41a\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866524078249,"sku":"260358","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-260358","provider":"Iright","version":"1.0","type":"link"}