{"product_id":"biolegend-300707","title":"Biolegend, 300707, Purified anti-human CD54 Antibody, 100μg","description":"\u003cp\u003eCD54, also known as ICAM-1, is a 85-110 kD type I transmembrane protein. It is expressed on activated endothelial cells, high endothelial venules, T and B cells, monocytes\/macrophages, granulocytes, and dendritic cells. The expression of ICAM-1 on the cell surface is potently upregulated by activation; a soluble form of ICAM-1 can be released from the cell surface. CD54 plays a role in cellular adhesion and is involved in inflammation and leukocyte extravasation. CD54 has also been shown to be the major cellular receptor for rhinovirus. ICAM-1 binds to CD11a\/CD18 (LFA-1), CD11b\/CD18 (Mac-1), CD11c\/CD18 (p150, 95) as well as hyaluronan and fibrinogen.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Transfectant cells (aa28-480) and recombinant protein (aa28-480)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Flow cytometry testing showed that clone W21128D can block the binding of clones HA58 and HCD54 on target cells.\u003cbr\u003e\nRRID: AB_3683299 (BioLegend Cat. No. 300707)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein\u003cbr\u003e\nDistribution: Activated endothelial cells, high endothelial venules, T cells and B cells, monocytes\/macrophages, granulocytes, dendritic cells. Cell surface expression upregulated upon activation; soluble ICAM-1 released from surface.\u003cbr\u003e\nFunction: Cellular adhesion, involved in inflammation and immune reactions. CD54 expressed on endothelial cells in areas of inflammation plays a role in leukocyte extravasation. Major cellular receptor for rhinovirus.\u003cbr\u003e\nLigand\/Receptor: CD11a\/CD18 (LFA-1), CD11b\/CD18 (Mac-1), CD11c\/CD18 (p150, 95) and has also been reported to bind hyaluronan and fibrinogen.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Endothelial cells, Granulocytes, Macrophages, Mesenchymal Stem Cells, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Voraberger G, et al. 1991 J Immunol. 147:2777-86. Staunton DE, et al. 1988. Cell. 52:925-33. Greve JM, et al. 1989. Cell. 56:839-47.\u003cbr\u003e\nGene ID: 3383\u003cbr\u003e\nUniProt: View information about CD54 on UniProt.org\u003cbr\u003e\nClone: W21128D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ICAM-1, Ly-47\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866430525609,"sku":"300707","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-300707","provider":"Iright","version":"1.0","type":"link"}