{"product_id":"biolegend-300803","title":"Biolegend, 300803, PE anti-human CD137 (4-1BB) Antibody, 25tests","description":"\u003cp\u003eCD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human CD137-Fc\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Yang L, et al. 2024. Sci Adv. eadj2445:10. PubMed Ringelstein-Harlev S, et al. 2023. Eur J Haematol. 110:371. PubMed\u003cbr\u003e\nRRID: AB_2860760 (BioLegend Cat. No. 300803) AB_2860761 (BioLegend Cat. No. 300804)\u003cbr\u003e\nStructure: TNFR superfamily, type I transmembrane protein, 30 kD\u003cbr\u003e\nDistribution: Activated T cells\u003cbr\u003e\nFunction: T cell costimulation\u003cbr\u003e\nLigand\/Receptor: 4-1BB ligand (CD137L)\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immuno-Oncology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Gruss HJ \u0026amp; Dower SK. 1995. Blood. 85:3378-404. Sica G \u0026amp; Chen L. 2000. Adv Exp Med Biol. 465:355-62. Alderson MR, et al. 1994. Eur J Immunol. 24:2219-27. Schwarz H, et al. 1996. Blood 87:2839-45.\u003cbr\u003e\nGene ID: 3604\u003cbr\u003e\nUniProt: View information about CD137 on UniProt.org\u003cbr\u003e\nClone: S18014C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 4-1BB, ILA, CDw137, TNFRSF9\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866246664361,"sku":"300803","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-300803","provider":"Iright","version":"1.0","type":"link"}