{"product_id":"biolegend-301506","title":"Biolegend, 301506, APC anti-human CD112R (PVRIG) Antibody, 100tests","description":"\u003cp\u003eCD112R gene encodes a single transmembrane protein consisting of a single extracellular IgV domain. Its long intracellular domain contains two tyrosine residues, one of which is within an ITIM-like motif. CD112R was initially named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR\/CD155) and polio virus receptor-like (PVRL) genes. CD112R is a cell surface receptor for CD112\/Nectin-2, it compete against CD226 in binding to CD112. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response. Published studies suggest that CD112R is a novel co-inhibitory receptor, or a checkpoint molecule, that suppressed TCR medicated signal.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human CD112R transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2876586 (BioLegend Cat. No. 301505) AB_2876586 (BioLegend Cat. No. 301506)\u003cbr\u003e\nStructure: IgV domain; ITIM motif\u003cbr\u003e\nDistribution: T cells, NK cells\u003cbr\u003e\nFunction: Cell surface receptor for CD112, negative regulator of T cell response\u003cbr\u003e\nLigand\/Receptor: CD112 (Nectin-2)\u003cbr\u003e\nCell Type: Leukocytes, Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immuno-Oncology, Immunology, Inhibitory Molecules\u003cbr\u003e\nMolecular Family: Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Xu F, et al. 2017. Cancer Immunol. Immunother. 66:1367-1375. Zhu Y, et al. 2016. J. Exp. Med. 213(2):167-76.\u003cbr\u003e\nGene ID: 79037\u003cbr\u003e\nUniProt: View information about CD112R on UniProt.org\u003cbr\u003e\nClone: W16216D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Poliovirus receptor-related immunoglobulin domain containing protein, PVRIG, C7orf15, CD112 receptor\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866309152937,"sku":"301506","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-301506","provider":"Iright","version":"1.0","type":"link"}