{"product_id":"biolegend-302601","title":"Biolegend, 302601, Purified anti-human CD25 Antibody, 25μg","description":"\u003cp\u003eCD25 is a 55 kD type I transmembrane glycoprotein also known as the low affinity IL-2 receptor α chain or Tac. It is expressed on progenitor lymphocytes, activated T and B cells, and activated monocytes\/macrophages. CD25 is also expressed on a subset of non-stimulated CD4 + T cells termed T regulatory cells. CD25 associates with the IL-2 receptor β (CD122) and common γ chains (CD132) to form the high affinity IL-2R complex.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Baboon, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested ICC - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications include: immunocytochemistry3.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. Kmieciak M, et al. 2009. J. Transl. Med. 7:89. (FC) PubMed Ernst CW, et al. 2007. Clin. Exp. Immunol. 148:271. (ICC) PubMed\u003cbr\u003e\nProduct Citations: Spoerl S, et al. 2021. Eur J Immunol. 51:1436. PubMed Alpert A, et al. 2022. Cell Syst. 13:71. PubMed Zhang H, et al. 2023. Nat Immunol. 24:96. PubMed Alroqi F, et al. 2017. J Clin Immunol. . 10.1007\/s10875-017-0451-1. PubMed Wang W, et al. 2018. Cancer Cell. 34:757. PubMed Volchenkov R, et al. 2017. Front Immunol. 0.818055556. PubMed Chakhtoura M, et al. 2021. PLoS Pathog. 17:e1009732. PubMed Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed Li Y, et al. 2019. Front Immunol. 0.460416667. PubMed Gunawan M, et al. 2017. Sci Rep. . 10.1038\/s41598-017-16999-7. PubMed Li H, et al. 2020. Front Immunol. 11:1777. PubMed Sharabi A, et al. 2019. JCI Insight. 4:e126294. PubMed Sattler A, et al. 2021. Am J Transplant. 21:87. PubMed Muhammad F, et al. 2020. J Autoimmun. 111:102441. PubMed Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed Ardain A, et al. 2019. Nature. 570:528. PubMed Martin E, et al. 2020. JCI Insight. :5. PubMed Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed Chiou SH, et al. 2021. Immunity. 54:586. PubMed\u003cbr\u003e\nRRID: AB_314272 (BioLegend Cat. No. 302602)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, 55 kD\u003cbr\u003e\nDistribution: Activated T cells and B cells, monocytes\/macrophages, Treg\u003cbr\u003e\nFunction: Associates with IL-2 receptor β (CD122) and γ chains (CD132) to form high affinity IL-2R complex\u003cbr\u003e\nLigand\/Receptor: IL-2\u003cbr\u003e\nCell Type: B cells, Macrophages, Monocytes, T cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Taniguchi T, et al. 1993. Cell 73:5. 2. Waldmann T. 1991. J. Biol. Chem. 266:2681.\u003cbr\u003e\nGene ID: 3559\u003cbr\u003e\nUniProt: View information about CD25 on UniProt.org\u003cbr\u003e\nClone: BC96\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V T-072\u003cbr\u003e\nOther Names: Low affinity IL-2R, IL-2R α chain, Tac, p55\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862904033449,"sku":"302601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-302601","provider":"Iright","version":"1.0","type":"link"}