{"product_id":"biolegend-305515","title":"Biolegend, 305515, PE\/Cyanine7 anti-human CD94 Antibody, 25tests","description":"\u003cp\u003eCD94 is a 43 kD type II transmembrane glycoprotein also known as KP43. CD94 belongs to the C-type lectin superfamily and is present as a covalently linked heterodimer with NKG2 on the cell surface. CD94 is expressed by NK cells, a subset of γδ T cells, and NKT cells. The CD94\/NKG2A complex serves as an inhibitory receptor specific for HLA-class I molecules.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: NK cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation4, inhibition of NK cell-mediated lysis5, immunohistochemical staining of acetone-fixed frozen tissue sections, and spatial biology (IBEX)6,7.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Mizuki M, et al. 2000. Sarcoidosis Vasc. Diffuse Lung Dis. 17:54. Phillip J, et al. 1996. Immunity 5:163. Lazetic S, et al. 1996. J. Immunol. 157:4741. Lanier LL, et al. 1998. Immunity 8:693. Wooden SL, et al. 2005. J. Immunol. 175:1383. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed\u003cbr\u003e\nProduct Citations: Rogers BM, et al. 2021. J Exp Med. 218:. PubMed Guo M, et al. 2021. Front Oncol. 11:632540. PubMed Mold JE, et al. 2021. Cell Reports. 35(8):109174. PubMed Collins PL et al. 2018. Cell. 176(1-2):348-360 . PubMed Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed\u003cbr\u003e\nRRID: AB_2632752 (BioLegend Cat. No. 305515) AB_2632753 (BioLegend Cat. No. 305516)\u003cbr\u003e\nStructure: C-type lectin, type II transmembrane glycoprotein, covalently associates with NKG2, 43 kD\u003cbr\u003e\nDistribution: NK cells , T subset\u003cbr\u003e\nFunction: Inhibits NK function\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Lopez-Botet M, et al. 1997. Immunol. Rev. 155:165. 2. Moretta A, et al. 1997. Immunol. Rev. 155:105.\u003cbr\u003e\nGene ID: 3824\u003cbr\u003e\nUniProt: View information about CD94 on UniProt.org\u003cbr\u003e\nClone: DX22\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: KP43\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863057322153,"sku":"305515","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-305515","provider":"Iright","version":"1.0","type":"link"}