{"product_id":"biolegend-307508","title":"Biolegend, 307508, Alexa Fluor® 647 anti-human CD161 Antibody, 100tests","description":"\u003cp\u003eCD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human CD161 transfected cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2910381 (BioLegend Cat. No. 307507) AB_2910381 (BioLegend Cat. No. 307508)\u003cbr\u003e\nStructure: Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily\u003cbr\u003e\nDistribution: NK cells, T subset, subset of CD3+ thymocytes\u003cbr\u003e\nLigand\/Receptor: LLT-1 (Lectin-like transcript-1)\u003cbr\u003e\nCell Type: NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Takahashi T, et al. 2006. J Immunol. 176:211-6. Cosmi L, et al. 2008. J Exp Med. 205:1903-16. Aldemir H, et al. 2005. J Immunol. 175:7791-5. Rosen DB, et al. 2008. J Immunol. 180:6508-17.\u003cbr\u003e\nGene ID: 3820\u003cbr\u003e\nUniProt: View information about CD161 on UniProt.org\u003cbr\u003e\nClone: W18070C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: NKR-P1A\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866330452137,"sku":"307508","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-307508","provider":"Iright","version":"1.0","type":"link"}