{"product_id":"biolegend-309206","title":"Biolegend, 309206, FITC anti-human CD2 Antibody, 100tests","description":"\u003cp\u003eCD2 is a 50 kD type I transmembrane glycoprotein also known as LFA-2, T11, and sheep red blood cell receptor (SRBC-R). This immunoglobulin superfamily member is expressed on thymocytes, T lymphocytes, NK cells, and thymic B cell subsets. The major ligand for CD2 is CD58 (also known as LFA-3). CD2 has also been reported to bind CD48, CD59, and CD15. CD2 plays a critical role in alternative T cell activation, T cell signaling, and cell-cell adhesion.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: blocking of T cell activation, and partial blocking of B cell costimulation2. The Ultra-LEAF™ purified antibody (Endotoxin \u0026lt; 0.01 EU\/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 309235 \u0026amp; 309236).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Schlossman S, et al. Eds.1995. Leucocyte Typing V Oxford University Press. New York. Hughes CCW, et al. 1996. J. Biol. Chem. 271:5369.\u003cbr\u003e\nProduct Citations: Congras A, et al. 2020. J Clin Invest. 130:6395. PubMed Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed Finkin S et al. 2019. Immunity. 51(2):324-336 . PubMed\u003cbr\u003e\nRRID: AB_314755 (BioLegend Cat. No. 309205) AB_314756 (BioLegend Cat. No. 309206)\u003cbr\u003e\nStructure: Ig superfamily, type I transmembrane glycoprotein, 50 kD\u003cbr\u003e\nDistribution: T cells, NK cells, thymocytes, and thymic B cell subsets\u003cbr\u003e\nFunction: T cell activation, adhesion\u003cbr\u003e\nLigand\/Receptor: CD58 (LFA-3), CD48, CD59, CD15\u003cbr\u003e\nCell Type: B cells, NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Bell G, et al. 1995. J. Immunol. 155:2805. 2. Bierer B, et al. 1989. Annu. Rev. Immunol. 7:579. 3. Moingeon P, et al. 1989. Immunol. Rev. 111:111.\u003cbr\u003e\nGene ID: 914\u003cbr\u003e\nUniProt: View information about CD2 on UniProt.org\u003cbr\u003e\nClone: TS1\/8\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V S025\u003cbr\u003e\nOther Names: LFA-2, T11, SRBC-R\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864012312745,"sku":"309206","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-309206","provider":"Iright","version":"1.0","type":"link"}