{"product_id":"biolegend-311906","title":"Biolegend, 311906, PE anti-human CD267 (TACI) Antibody, 100tests","description":"\u003cp\u003eTACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs). Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins (BAFF\/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-κ B and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: TACI-transfected RBL cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ng LG, et al.2004. J. Immunol. 173:807. (FC) Lougaris V, et al. 2012. Hum Immunol. 73:836. PubMed.\u003cbr\u003e\nProduct Citations: Rossi M, et al. 2023. Elife. 12:. PubMed Lepse N, et al. 2016. Rheumatology. 55: 162 - 172. PubMed Meng L, et al. 2021. Front Oncol. 11:691705. PubMed Salazar-Camarena D, et al. 2016. Lupus. 25: 582 - 592. PubMed Tai YT, et al. 2019. Leukemia. 33:426. PubMed Flint S, et al. 2016. Haematologica. 101: 698 - 706. PubMed\u003cbr\u003e\nRRID: AB_2203401 (BioLegend Cat. No. 311906)\u003cbr\u003e\nStructure: Type III transmembrane protein, TNF receptor superfamily, 32 kD\u003cbr\u003e\nDistribution: B cells, meyloma cells\u003cbr\u003e\nFunction: Negative regulation of B cell function\u003cbr\u003e\nLigand\/Receptor: BAFF\/BLys, April, Syndecan-2\u003cbr\u003e\nCell Type: B cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Gross JA, et al. 2000. Nature 404:995. 2. Wu Y, et al. 2000. J. Biol Chem. 275:35478. 3. Yan M, et al. 2001. Nat. Immunol. 2:638. 4. Hymowitz A, et al. 2005. J. Biol. Chem. 280:7218. 5. Bischof D, et al. 2006. BLOOD 107:3235.\u003cbr\u003e\nGene ID: 23495\u003cbr\u003e\nUniProt: View information about CD267 on UniProt.org\u003cbr\u003e\nClone: 1A1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF13B, CD267, Transmembrane Activator and CAML Interactor (TACI)\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860833325225,"sku":"311906","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-311906","provider":"Iright","version":"1.0","type":"link"}