{"product_id":"biolegend-312408","title":"Biolegend, 312408, PE anti-human CD120b Antibody, 100tests","description":"\u003cp\u003eCD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: CD120b recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_3716931 (BioLegend Cat. No. 312407) AB_3716931 (BioLegend Cat. No. 312408)\u003cbr\u003e\nStructure: 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI\u003cbr\u003e\nDistribution: Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes\u003cbr\u003e\nFunction: When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 which possess E3 ubiquitin ligase activity; cysteine rich extracellular region\u003cbr\u003e\nInteraction: Interacts with TTRAP and TRAF2\u003cbr\u003e\nLigand\/Receptor: TNF-α and TNF-β (LT-α)\u003cbr\u003e\nCell Type: Granulocytes, Lymphocytes, Monocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Andrews JS, et al. 1990. J Immunol. 144:2582-91. Nophar Y, et al. 1990. EMBO J. 9:3269-78. Kohno T, et al. 1990. Proc Natl Acad Sci USA. 87:8331. Tartaglia LA, et al. 1991. Proc Natl Acad. Sci USA. 88:9292. Hijdra D, et al. 2012. J Inflamm (Lond). 9:38. Chen X, et al. 2013. J Immunol. 190:1076-84.\u003cbr\u003e\nGene ID: 7133\u003cbr\u003e\nUniProt: View information about CD120b on UniProt.org\u003cbr\u003e\nClone: A22092I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866077221033,"sku":"312408","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-312408","provider":"Iright","version":"1.0","type":"link"}