{"product_id":"biolegend-314209","title":"Biolegend, 314209, Purified anti-human CA19-9 Antibody, 100μg","description":"\u003cp\u003eCarbohydrate Antigen 19-9 (CA19-9), also known as sialyl-Lewis A, is a cell surface glycoprotein complex. CA 19-9 expression requires the Lewis gene product, 1,4-fucosyltransferase, found only in patients with Le (a-b+) or Le (a+b-) blood groups. CA19-9 antigen is highly expressed in a variety of gastrointestinal epithelial malignancies including colon cancer and pancreatic cancer, and in breast cancer and small cell lung cancer, but has a limited expression on normal tissues.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Immunoprecipitate obtained after immunodiffusion of MAb 19-9 and mucins isolated from an ovarian cyst of a 0Le(a+b-) patient\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ragupathi G, et al. 2009. Cancer Immunol Immunother. 58:1397. Herrero-Zabaleta ME, et al. 1987. Bull Cancer. 74:387.\u003cbr\u003e\nRRID: AB_3698970 (BioLegend Cat. No. 314209)\u003cbr\u003e\nStructure: Branched tetrasaccharide with the sequence Neu5Acα2-3Galβ1-3[Fucα1-4]GlcNAcβ\u003cbr\u003e\nFunction: Elevated levels of CA19-9 can indicate the presence of pancreatic cancer, but it can also be raised in other cancers such as colorectal, stomach, and liver\u003cbr\u003e\nLigand\/Receptor: sLea is known to be the ligand for endothelial cell selectins\u003cbr\u003e\nMolecular Family: Adhesion Molecules, Blood Group Markers, Cytokines\/Chemokines, Enzymes and Regulators\u003cbr\u003e\nGene ID: NA\u003cbr\u003e\nClone: 121SLE\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Sialyl Lewis a, 3-Sialyl Lewis, SLea, Sialyl Lewis A, Sodium Salt\u003cbr\u003e\nIsotype: Mouse IgM, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860794134697,"sku":"314209","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-314209","provider":"Iright","version":"1.0","type":"link"}