{"product_id":"biolegend-316302","title":"Biolegend, 316302, Purified anti-human β2-microglobulin Antibody, 100μg","description":"\u003cp\u003eβ2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3\/TCR complex of CD8 + T cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus, Pig\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified human β2-microglobulin\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested WB, ELISA - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blotting, and ELISA.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Meissner TB, et al. 2010. Proc Natl Acad Sci USA. PubMed Rizvi SM, et al. 2011. J. Immunol. 186:2309. PubMed Meissner TB, et al. 2012. J Immunol. 188:4951. PubMed.\u003cbr\u003e\nProduct Citations: Saotome K, et al. 2023. Nat Commun. 14:2401. PubMed Leader AM, et al. 2021. Cancer Cell. 39:1594. PubMed Chou JM, et al. 2022. Front Microbiol. 13:883597. PubMed de Jong SE, et al. 2021. Nature Immunology. 22(5):654-665. PubMed Meissner T, et al. 2012. J Immunol. 188:4951. PubMed Peterson L, et al. 2011. J Immunol. 186:2309. PubMed Meissner T, et al. 2010. Proc Natl Acad Sci U S A. 88:737. PubMed Eccles JD, et al. 2020. Cell Rep. 30:351. PubMed Obiedat A, et al. 2020. J Mol Med (Berl). 98:135. PubMed Bulyáki É, et al. 2021. Biology (Basel). 10:. PubMed Georg P, et al. 2022. Cell. 185:493. PubMed Lim J, et al. 2020. Sci Rep. 10:14897. PubMed\u003cbr\u003e\nRRID: AB_492835 (BioLegend Cat. No. 316302)\u003cbr\u003e\nStructure: Nonpolymorphic Ig like structure, noncovalently associated with heavy chain of MHC class I molecules, 12 kD\u003cbr\u003e\nDistribution: Leukocytes, platelets, endothelial cells, epithelial cells\u003cbr\u003e\nFunction: Govern MHC class I molecule stability, promote MHC class I molecules binding and presenting peptide antigens to CD8+ T cells\u003cbr\u003e\nLigand\/Receptor: CD3\/TCR complex, CD8\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Leukocytes, Platelets\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nAntigen References: 1. Engelhard VH. 1994. Curr. Opin. Immunol. 6:13. 2. Williams DB, et al. 1989. J. Immunol. 142:2796. 3. Danliczyk UG and TL. Delovitch. 1994. J. Immunol. 153:3533. 4. Williams A, et al. 2002. Tissue Antigens 59:3.\u003cbr\u003e\nGene ID: 567\u003cbr\u003e\nUniProt: View information about beta2-microglobulin on UniProt.org\u003cbr\u003e\nClone: 2M2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: β2M, β2-M, beta2-microglobulin b2-M, b2M\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866449105065,"sku":"316302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-316302","provider":"Iright","version":"1.0","type":"link"}