{"product_id":"biolegend-316414","title":"Biolegend, 316414, Purified anti-human CD158a (KIR2DL1) Antibody, 100μg","description":"\u003cp\u003eCD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.  CD158a, also known as KIR2DL1, is a 38 kD, two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL1 has been reported to bind certain HLA-C antigens on target cells (HLA-C*02, HLA-C*04, HLAC*06, for example).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human KIR2DL1 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone S22039A does not block binding of clones HP-DM1 and HP-MA4 on target cells. Based on in-house testing on different KIR-expressing transfectants, clone S22039A does not interact with other KIR protein family members.\u003cbr\u003e\nRRID: AB_3683333 (BioLegend Cat. No. 316414)\u003cbr\u003e\nStructure: 38 kD two Ig-like extracellular domain glycoprotein\u003cbr\u003e\nDistribution: Subset of NK cells, subset of T Cells\u003cbr\u003e\nFunction: NK cell regulation\u003cbr\u003e\nLigand\/Receptor: Some HLA-C molecules\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Vilches C, et al. 2002. Annu Rev Immunol. 92.107361. Middleton, D. et al. 2010. Immunol. 123:8. Fan QR. et al. 2004. Blood. 103:5.\u003cbr\u003e\nGene ID: 3802\u003cbr\u003e\nUniProt: View information about CD158a on UniProt.org\u003cbr\u003e\nClone: S22039A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD158a, Killer Cell Immunoglobulin-Like Receptor 2DL1, NKAT1, p58.1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866278482089,"sku":"316414","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-316414","provider":"Iright","version":"1.0","type":"link"}