{"product_id":"biolegend-316415","title":"Biolegend, 316415, PE anti-human CD158a (KIR2DL1) Antibody, 25tests","description":"\u003cp\u003eCD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.  CD158a, also known as KIR2DL1, is a 38 kD, two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL1 has been reported to bind certain HLA-C antigens on target cells (HLA-C*02, HLA-C*04, HLAC*06, for example).\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human KIR2DL1 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone S22039A does not block binding of clones HP-DM1 and HP-MA4 on target cells. Based on in-house testing on different KIR-expressing transfectants, clone S22039A does not interact with other KIR protein family members.\u003cbr\u003e\nRRID: AB_3698972 (BioLegend Cat. No. 316415) AB_3698972 (BioLegend Cat. No. 316416)\u003cbr\u003e\nStructure: 38 kD two Ig-like extracellular domain glycoprotein\u003cbr\u003e\nDistribution: Subset of NK cells, subset of T Cells\u003cbr\u003e\nFunction: NK cell regulation\u003cbr\u003e\nLigand\/Receptor: Some HLA-C molecules\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Vilches C, et al. 2002. Annu Rev Immunol. 92.107361. Middleton, D. et al. 2010. Immunol. 123:8. Fan QR. et al. 2004. Blood. 103:5.\u003cbr\u003e\nGene ID: 3802\u003cbr\u003e\nUniProt: View information about CD158a on UniProt.org\u003cbr\u003e\nClone: S22039A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD158a, Killer Cell Immunoglobulin-Like Receptor 2DL1, NKAT1, p58.1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866278449321,"sku":"316415","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-316415","provider":"Iright","version":"1.0","type":"link"}