{"product_id":"biolegend-316932","title":"Biolegend, 316932, Brilliant Violet 421™ anti-human CD268 (BAFF-R) Antibody, 100tests","description":"\u003cp\u003eB cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF\/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: BAFF-R-L1.2 transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450\/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC) Personal communication. (Block)\u003cbr\u003e\nRRID: AB_3083307 (BioLegend Cat. No. 316931) AB_3083307 (BioLegend Cat. No. 316932)\u003cbr\u003e\nStructure: Type III transmembrane protein, TNF receptor superfamily, 19 kD\u003cbr\u003e\nDistribution: Mature B cells, B cell lymphoma, T cell subset\u003cbr\u003e\nFunction: Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation\u003cbr\u003e\nLigand\/Receptor: BAFF\/BLys, associate with TRAF3\u003cbr\u003e\nCell Type: B cells, Leukemia, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Thompson JS, et al. 2001. Science 293:2108. 2. Ng LG, et al.2004. J. Immunol. 173:807. 3. Rodig SJ, et al. 2005. Human Pathol. 36:1113. 4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750. 5. Kayagaki N, et al. 2002 Immunity 17:515.\u003cbr\u003e\nGene ID: 115650\u003cbr\u003e\nUniProt: View information about CD268 on UniProt.org\u003cbr\u003e\nClone: 11C1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What is the F\/P ratio range of our BV421™ format antibody reagents?\u003cbr\u003e\nA: It is lot-specific. On average it ranges between 2-4.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860792692905,"sku":"316932","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-316932","provider":"Iright","version":"1.0","type":"link"}