{"product_id":"biolegend-318303","title":"Biolegend, 318303, FITC anti-human CD56 (NCAM) Antibody, 25tests","description":"\u003cp\u003eCD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed\u003cbr\u003e\nProduct Citations: Korniotis S, et al. 2022. J Cell Sci. 135:. PubMed Porbahaie M, et al. 2023. PLoS One. 18:e0279626. PubMed Freund EC, et al. 2023. Methods Mol Biol. 2618:201. PubMed Carre C, et al. 2021. iScience. 24:102970. PubMed Kim MY, et al. 2021. JCI Insight. 6:. PubMed Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed Yuan H, et al. 2022. J Clin Exp Hematop. 62:52. PubMed Dorna J, et al. 2022. Front Immunol. 13:827760. PubMed Nakano M, et al. 2021. Front Immunol. 12:713225. PubMed Barry KC, et al. 2018. Nat Med. 24:1178. PubMed Hagan T, et al. 2020. Cell. 178(6):1313-1328.e13.. PubMed Nakajima K, et al. 2011. J Immunol. 186:4481. PubMed Hess NJ, et al. 2020. J Immunol. 205:272. PubMed Palamides P, et al. 2016. Dis Model Mech. 9: 985 - 997. PubMed Sutton HJ, et al. 2021. Cell Reports. 34(6):108684. PubMed Gorvel L, et al. 2017. J Immunol. 10.4049\/jimmunol.1601477. PubMed Devalraju KP, et al. 2021. PLoS One. 16:e0257185. PubMed Kobayashi Y, et al. 2020. Int J Oncol. 999:56. PubMed Agha O, et al. 2020. JOR Spine. 3:e1091. PubMed Kim ST, et al. 2022. Nat Commun. 13:1970. PubMed Fisher J, et al. 2017. Mol Ther. 10.1016\/j.ymthe.2017.03.002. PubMed Cai D, et al. 2021. Front Mol Biosci. 8:686803. PubMed Sweeney EE, et al. 2020. Nano Res. 13:736. PubMed Brown CC, et al. 2020. Cell. 179(4):846-863.e24.. PubMed Wang F, et al. 2021. Cell. 184(2):422-440.e17. PubMed Zhu Y, et al. 2019. Cell Stem Cell. 25:542. PubMed Huang Y, et al. 2008. J Immunol. 180:2367. PubMed Bochem J, et al. 2019. PLoS One. 14:e0221301. PubMed Zhang X, et al. 2021. Front Immunol. 12:602492. PubMed Xu P, et al. 2020. Cancer Immunol Res. 8:1193. PubMed Li YR, et al. 2021. Cell Rep Med. 2:100449. PubMed Horn LA, et al. 2017. Oncotarget. 8:57964. PubMed Motwani MP, et al. 2018. JCI Insight. 3:e94463. PubMed Yao C, et al. 2018. Autophagy. 1.854861111. PubMed Bradley D, et al. 2022. Nat Commun. 13:5606. PubMed Weiss R, et al. 2021. Cells. 10:. PubMed Kim ST, et al. 2021. J Immunother Cancer. 9:. PubMed Kwok I, et al. 2020. Immunity. 53(2):303-318.e5. PubMed Beyer AI, et al. 2017. Stem Cells Dev. 26:102. PubMed Ruth JH, et al. 2021. JCI Insight. 6:e145662. PubMed Wang SQ, et al. 2021. J Viral Hepat. 28:795. PubMed Pappa V, et al. 2021. J Neuroimmunol. 353:577524. PubMed Kim N, et al. 2020. Nat Commun. 2.045138889. PubMed Ceglia V, et al. 2022. Front Immunol. 12:786144. PubMed\u003cbr\u003e\nRRID: AB_604091 (BioLegend Cat. No. 318303) AB_604100 (BioLegend Cat. No. 318304)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein\u003cbr\u003e\nDistribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Heparin sulfate\u003cbr\u003e\nCell Type: B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Lanier L, et al. 1991. J. Immunol. 146:4421. 2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71. 3. Cremer H, et al. 1994. Nature 367:455.\u003cbr\u003e\nGene ID: 4684\u003cbr\u003e\nUniProt: View information about CD56 on UniProt.org\u003cbr\u003e\nClone: HCD56\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leu-19, NKH1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866453364905,"sku":"318303","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-318303","provider":"Iright","version":"1.0","type":"link"}