{"product_id":"biolegend-318318","title":"Biolegend, 318318, PE\/Cyanine7 anti-human CD56 (NCAM) Antibody, 100tests","description":"\u003cp\u003eCD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed\u003cbr\u003e\nProduct Citations: Calabrese DR, et al. 2020. J Clin Invest. . PubMed Hagel J, et al. 2021. J Immunol. 206:3073. PubMed Andreano E, et al. 2023. Nat Commun. 14:53. PubMed Tunali G, et al. 2023. J Clin Invest. :. PubMed Wang H, et al. 2022. Front Immunol. 13:852436. PubMed Wiernik A, et al. 2013. Clin Cancer Res. 19:3844. PubMed Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed Park SY, et al. 2022. NPJ Vaccines. 7:123. PubMed Kim JT, et al. 2022. Nat Commun. 13:121. PubMed Figueroa-Romero C, et al. 2022. Front Immunol. 13:773288. PubMed Chen M, et al. 2021. Cancers (Basel). 13:. PubMed Wurzer H, et al. 2021. Front Immunol. 12:619069. PubMed Bernareggi D, et al. 2022. Nat Commun. 13:1899. PubMed Romee R, et al. 2013. Blood. 121:3599. PubMed Cheent K, et al. 2013. Proc Natl Acad Sci U S A. 110:16981. PubMed Gleason M, et al. 2014. Blood. 123:3016. PubMed Mao Y, et al. 2016. Blood. 128: 1475 - 1489. PubMed Arvindam US, et al. 2021. Leukemia. 35:1586. PubMed Izmirly AM, et al. 2022. PLoS Pathog. 18:e1009903. PubMed Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed Nabet BY, et al. 2020. Cell. 183(2):363-376.e13. PubMed Laroni A, et al. 2016. J Autoimmun. 72:8-18. PubMed Cooper GE, et al. 2018. Front Immunol. 9:1671. PubMed Singh N, et al. 2017. J Endocrinol. 235:69. PubMed , et al. 2021. Eur J Immunol. 51:2708. PubMed Liu Y, et al. 2017. Oncogene. 10.1038\/onc.2017.209. PubMed Hakimi AA, et al. 2019. Cancer Discov. 9:510. PubMed Mishra HK, et al. 2021. Front Immunol. 12:711621. PubMed Zhu S, et al. 2022. J Oncol. 2022:8724933. PubMed Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed Madhavi V, et al. 2015. J Infect Dis. 211:529. PubMed Murdock BJ, et al. 2021. JCI Insight. 6:. PubMed Gleason M, et al. 2012. Mol Cancer Ther. 11:2674. PubMed Hansen A, et al. 2016. Sci Rep. 6:35406. PubMed Terszowski G, et al. 2014. J Immunol. 192:5618. PubMed Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed Felices M, et al. 2018. JCI Insight. 3. PubMed Fisher JG, et al. 2021. Front Oncol. 11:785635. PubMed Zhao NQ, et al. 2020. PLoS One. 15:e0238347. PubMed Pi J, et al. 2022. J Nanobiotechnology. 20:36. PubMed Andreano E, et al. 2021. Nature. Online ahead of print. PubMed Van der Meer JM, et al. 2020. Cancer Immunol Immunother. . PubMed Chen YP, et al. 2020. Cell Res. 30:1024. PubMed Woods E, et al. 2021. NPJ Vaccines. 6:117. PubMed Agelidis A, et al. 2017. Cell Rep. 10.1016\/j.celrep.2017.06.041. PubMed Kwant-Mitchell A, et al. 2009. PLoS One. 4:e8379. PubMed Zhang C, et al. 2021. Cancer Biol Med. :. PubMed Kucykowicz S, et al. 2022. STAR Protoc. 3:101356. PubMed Parent AV, et al. 2021. Cell Reports. 36(7):109538. PubMed Sadallah S, et al. 2016. J Immunol. 197: 1663 - 1671. PubMed Vallera D, et al. 2016. Clin Cancer Res. 22: 3440 - 3450. PubMed Wang S, et al. 2022. Cancer Immunol Immunother. Online ahead of print. PubMed\u003cbr\u003e\nRRID: AB_604099 (BioLegend Cat. No. 318317) AB_604107 (BioLegend Cat. No. 318318)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein\u003cbr\u003e\nDistribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Heparin sulfate\u003cbr\u003e\nCell Type: B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Lanier L, et al. 1991. J. Immunol. 146:4421. 2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71. 3. Cremer H, et al. 1994. Nature 367:455.\u003cbr\u003e\nGene ID: 4684\u003cbr\u003e\nUniProt: View information about CD56 on UniProt.org\u003cbr\u003e\nClone: HCD56\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leu-19, NKH1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866454315177,"sku":"318318","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-318318","provider":"Iright","version":"1.0","type":"link"}