{"product_id":"biolegend-318320","title":"Biolegend, 318320, Biotin anti-human CD56 (NCAM) Antibody, 100μg","description":"\u003cp\u003eCD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality testedIF - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed\u003cbr\u003e\nProduct Citations: Benjamin DI, et al. 2022. Cell Metab. 34:902. PubMed Wei X, et al. 2022. Mol Cell. 82:1225. PubMed Riether C, et al. 2021. Cell Reports. 34(4):108663. PubMed Hinterbrandner M, et al. 2021. JCI Insight. 6:e151797. PubMed Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed Bourdely P, et al. 2020. Immunity. 53(2):335-352. PubMed Sarkar TJ, et al. 2020. Nat Commun. 11:1545. PubMed Quarta M, et al. 2016. Nat Biotechnol. 10.1038\/nbt.3576. PubMed Goods BA, et al. 2021. JCI Insight. 6: . PubMed An X, et al. 2017. PLoS One.. 10.1371\/journal.pone.0181904. PubMed Hirota K et al. 2018. Immunity. 48(6):1220-1232 . PubMed Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed Askenase MH, et al. 2021. Sci Immunol. 6:. PubMed\u003cbr\u003e\nRRID: AB_893392 (BioLegend Cat. No. 318319) AB_893390 (BioLegend Cat. No. 318320)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein\u003cbr\u003e\nDistribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Heparin sulfate\u003cbr\u003e\nCell Type: B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Lanier L, et al. 1991. J. Immunol. 146:4421. 2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71. 3. Cremer H, et al. 1994. Nature 367:455.\u003cbr\u003e\nGene ID: 4684\u003cbr\u003e\nUniProt: View information about CD56 on UniProt.org\u003cbr\u003e\nClone: HCD56\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leu-19, NKH1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866453430441,"sku":"318320","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-318320","provider":"Iright","version":"1.0","type":"link"}