{"product_id":"biolegend-318321","title":"Biolegend, 318321, PerCP\/Cyanine5.5 anti-human CD56 (NCAM) Antibody, 25tests","description":"\u003cp\u003eCD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PerCP\/Cyanine5.5 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The CD56 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. * PerCP\/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.\u003cbr\u003e\nAdditional Product Notes: View more applications data for this product in our Scientific Poster Library.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed\u003cbr\u003e\nProduct Citations: Vielle NJ, et al. 2018. Sci Rep. 8:5440. PubMed Shen Q, et al. 2022. Cancer Res Commun. 2:258. PubMed Shemesh A, et al. 2022. J Exp Med. 219: . PubMed Edwards CL, et al. 2023. J Clin Invest. 133: . PubMed Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed Montes de Oca M, et al. 2016. Cell Rep. 17:399-412. PubMed de Jonge K et al. 2019. Scientific reports. 9(1):4487 . PubMed Kuang Z, et al. 2020. Antib Ther. 3:227. PubMed Walk J, et al. 2019. Nat Commun. 10:874. PubMed Yokoyama K, et al. 2022. Front Immunol. 13:1016914. PubMed Jürchott K, et al. 2016. PLoS One. 11: 0150812. PubMed Ponath V, et al. 2021. Int J Mol Sci. 22:. PubMed Webb K et al. 2018. Frontiers in immunology. 2.574305556 . PubMed Gannon PO, et al. 2020. Cytotherapy. 22(12):780-791. PubMed Ciccia F, et al. 2012. Ann Rheum Dis. 71:295. PubMed Shemesh A, et al. 2022. J Exp Med. 219:. PubMed McDonnell A, et al. 2017. BMC Cancer . 10.1186\/s12885-017-3403-5. PubMed Theurich S et al. 2017. Cell metabolism. 26(1):171-184 . PubMed Teirlinck A, et al. 2015. Infect Immun . 83: 3732-3739. PubMed Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed\u003cbr\u003e\nRRID: AB_893391 (BioLegend Cat. No. 318321) AB_893389 (BioLegend Cat. No. 318322)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein\u003cbr\u003e\nDistribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Heparin sulfate\u003cbr\u003e\nCell Type: B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Lanier L, et al. 1991. J. Immunol. 146:4421. 2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71. 3. Cremer H, et al. 1994. Nature 367:455.\u003cbr\u003e\nGene ID: 4684\u003cbr\u003e\nUniProt: View information about CD56 on UniProt.org\u003cbr\u003e\nClone: HCD56\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leu-19, NKH1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: How stable is PerCP\/Cyanine5.5 tandem as compared to PerCP alone?\u003cbr\u003e\nA: PerCP\/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866454577321,"sku":"318321","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-318321","provider":"Iright","version":"1.0","type":"link"}