{"product_id":"biolegend-322601","title":"Biolegend, 322601, Purified anti-human CD62E Antibody, 25μg","description":"\u003cp\u003eCD62E (also known as E-selectin, ELAM-1, and LECAM-1) is a 115 kD type I membrane protein and a member of the selectin family. CD62E is highly expressed on activated endothelial cells (IL-2, TNF-α, other cytokines can increase expression) and can also be expressed on endothelial cells in the skin, bone marrow and placenta. CD62E is involved in tethering and leucocyte rolling on activated endothelium at inflammatory sites and may also play a role in tumor metastasis and angiogenesis. CD62E binds to both Siayl Lewis X (CD15s) and PSGL-1 (CD162). The HCD62E antibody has been shown to recognize human CD62E and to be useful for flow cytometry.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Gunasekaran M, et al. 2018. J Immunol. 200:2535. PubMed\u003cbr\u003e\nRRID: AB_536004 (BioLegend Cat. No. 322602)\u003cbr\u003e\nStructure: Member of the selectin family, 115 kD type I membrane protein; contains one C-type lectin domain and one EGF-like domain\u003cbr\u003e\nDistribution: Highly expressed on activated endothelial cells (IL-2, TNF-α, other cytokines can increase expression); can also be expressed on endothelial cells in the skin, bone marrow and placenta.\u003cbr\u003e\nFunction: Involved in tethering and leucocyte rolling on activated endothelium at inflammatory sites, may also play a role in tumor metastasis and angiogenesis\u003cbr\u003e\nLigand\/Receptor: Siayl Lewis X (CD15s) and PSGL-1 (CD162) bind to CD62E. Recently, CLA (cutaneous lymphocyte antigen) has also been reported in interact with CD62E\u003cbr\u003e\nCell Type: Endothelial cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Collins T, et al. 1991. J. Biol. Chem. 266:2466. 2. Bevilacqua MP, et al. 1987. Proc. Natl. Acad. Sci. USA 84:9238. 3. Berg EL, et al. 1991. J. Exp. Med. 174:1461. 4. Lawrence MB, et al. 1993. J. Immunol. 151:6338. 5. Walz G, et al. 1990. Science 250:1132.\u003cbr\u003e\nGene ID: 6401\u003cbr\u003e\nUniProt: View information about CD62E on UniProt.org\u003cbr\u003e\nClone: HCD62E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: E-selectin, ELAM-1, LECAM-1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866455396521,"sku":"322601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-322601","provider":"Iright","version":"1.0","type":"link"}