{"product_id":"biolegend-327406","title":"Biolegend, 327406, PE anti-human SUSD2 Antibody, 100tests","description":"\u003cp\u003eThe W5C5 antibody reacts with SUSD2 (sushi domain containing 2) which is expressed by bone marrow mesenchymal stem cells, vessel-surrounding smooth muscle cells, and a few neoplastic cell lines. SUSD2 is a recently identified type I transmembrane protein of 820 amino acids consisting of a large extracellular region containing a Somatomedin B (SMB), an Adhesion-associated domain in MUC4 and Other Proteins (AMOP), a von Willebrand factor (vWF), and a F1c Sushi domain. Mesenchymal stem cells (MSCs) were originally named bone marrow stromal cells. They are a population of adult stem cells with a large capacity for self-renewal and multipotency for differentiation into a variety of cell types including osteoblasts, chondrocytes, myocytes, adipocytes, β-pancreatic islets cells, and certain neuronal cells. MSCs reside in many cells and tissues, such as bone marrow, placenta, adipose tissue, adult peripheral blood, fetal blood, skin, liver, and lung. Besides their plasticity for tissue repair, MSCs also exhibit powerful immunosuppressive activity and play an important role in supporting hematopoiesis.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Retinoblastoma cell line (Weri-RB-1 cells).\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunofluorescence2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Masuda H, et al. 2012. Cell Transplant. 21:2201. Sivasubramaniyan K, et al. 2013. Stem Cells Dev. 22:1944. PubMed (IF) Su K, et al. 2014. Acta Biomater. 10:5012. PubMed\u003cbr\u003e\nProduct Citations: Yu L, et al. 2020. Cell Stem Cell. 28(3):550-567.e12. PubMed Patani H, et al. 2020. Nat Commun. 3.007638889. PubMed Rohani L, et al. 2020. Commun Biol. 0.466666667. PubMed Ulrich D, et al. 2014. Hum Reprod. 29:1895. PubMed Bredenkamp N, et al. 2019. Stem Cell Reports. 1.29375. PubMed Aints A, et al. 2019. Sci Rep. 9:12562. PubMed Dong C, et al. 2022. Nat Commun. 13:2548. PubMed Miller SA, et al. 2021. Cancer Res. 81:3791. PubMed Huang X, et al. 2021. Nat Commun. 12:5123. PubMed Sivasubramaniyan K, et al. 2013. Stem Cells Dev. 22:1944. PubMed Khan SA, et al. 2021. Cell Reports. 35(11):109233. PubMed Chen C, et al. 2022. iScience. 25:103645. PubMed\u003cbr\u003e\nRRID: AB_940654 (BioLegend Cat. No. 327406)\u003cbr\u003e\nDistribution: Bone marrow mesenchymal stem cells\u003cbr\u003e\nCell Type: Mesenchymal cells, Mesenchymal Stem Cells\u003cbr\u003e\nBiology Area: Immunology, Stem Cells\u003cbr\u003e\nAntigen References: 1. Buhring HJ, et al. 2007. Ann. N. Y. Acad. Sci. 1106:262. 2. Jackson L, et al. 2007. J. Postgrad. Med. 53:121. 3. Krampera M, et al. 2003. Blood 101:3722. 4. Ball LM, et al. 2007. Blood 110:2764.\u003cbr\u003e\nGene ID: 56241\u003cbr\u003e\nUniProt: View information about SUSD2 on UniProt.org\u003cbr\u003e\nClone: W5C5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Mesenchymal Stem Cells (MSC), Sushi domain containing 2 (SUSD2)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864086040745,"sku":"327406","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-327406","provider":"Iright","version":"1.0","type":"link"}