{"product_id":"biolegend-329805","title":"Biolegend, 329805, PE anti-human CD275 (B7-H2, B7-RP1, ICOSL) Antibody, 25tests","description":"\u003cp\u003eB7-H2, a member of the B7 family and the immunoglobulin superfamily, is a 40 kD protein also known as B7RP-1, B7h, B7-H2, GL50 and ICOS Ligand. Human B7-H2 is expressed by B lymphocytes, activated monocytes\/macrophages, and dendritic cells. B7-H2 binds to a CD28-like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. The interaction of ICOS with B7-H2 plays an important role in the T cell costimulation pathway.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human B7H2-mIg fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Qian X, et al. 2006. Eur J Immunol. 36:906-918. Ribot JC, et al. 2012. J. Immunol. 189:1202. PubMed.\u003cbr\u003e\nProduct Citations: Li H, et al. 2016. J Immunol. 196: 4064 - 4074. PubMed\u003cbr\u003e\nRRID: AB_2280082 (BioLegend Cat. No. 329805) AB_2280081 (BioLegend Cat. No. 329806)\u003cbr\u003e\nStructure: Ig superfamily, B7 family, 40 kD\u003cbr\u003e\nDistribution: B cells and dendritic cells\u003cbr\u003e\nFunction: Binds ICOS on antigen-activated T cells and mediates proliferation and cytokine production\u003cbr\u003e\nLigand\/Receptor: ICOS\u003cbr\u003e\nCell Type: B cells, Dendritic cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Qian X, et al. 2006. Eur J Immunol. 36:906-918.\u003cbr\u003e\nGene ID: 23308\u003cbr\u003e\nUniProt: View information about CD275 on UniProt.org\u003cbr\u003e\nClone: 9F.8A4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: B7-H2, B7H2, B7-RP1, ICOSL, ICOS-L\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862511931561,"sku":"329805","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-329805","provider":"Iright","version":"1.0","type":"link"}