{"product_id":"biolegend-330001","title":"Biolegend, 330001, Purified anti-human CD50 (ICAM-3) Antibody, 25μg","description":"\u003cp\u003eCD50 is a 120-140 kD type I membrane protein also known as intercellular adhesion molecule 3 (ICAM-3). It is broadly expressed on leukocytes, endothelial cells, and Langerhans cells. CD50 is a member of the Ig superfamily. It provides costimulatory signal for T cells and regulates cell adhesion through interaction with LFA-1 (CD11a\/CD18, α L \/β 2 ) integrin.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Baboon, Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: SKW3 cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications include: immunoprecipitation1 and blocking1-3.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): deFougerolles AR and Springer TA, et al. 1992. J. Exp. Med. 175:185. (IP, Block) Geijtenbeek T, et al. 2000. Cell 100:575. (Block) Giannoni E, et al. 2003. J Biol. Chem. 278:36763. (Block)\u003cbr\u003e\nProduct Citations: Sugden SM, et al. 2017. J Virol. 91:e02445. PubMed\u003cbr\u003e\nRRID: AB_1186142 (BioLegend Cat. No. 330002)\u003cbr\u003e\nStructure: Ig superfamily, type I membrane protein, 130 kD\u003cbr\u003e\nDistribution: Thymocytes, T and B cells, monocytes, granulocytes, endothelial cells\u003cbr\u003e\nFunction: Adhesion, costimulation\u003cbr\u003e\nLigand\/Receptor: CD11a\/CD18 (LFA-1), integrin αL\/ß2\u003cbr\u003e\nCell Type: B cells, Endothelial cells, Granulocytes, Monocytes, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Valent P, et al. 2001. Immunol. Rev. 179:74.\u003cbr\u003e\nGene ID: 3385\u003cbr\u003e\nUniProt: View information about CD50 on UniProt.org\u003cbr\u003e\nClone: CBR-IC3\/1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ICAM-3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862971404457,"sku":"330001","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-330001","provider":"Iright","version":"1.0","type":"link"}