{"product_id":"biolegend-332805","title":"Biolegend, 332805, APC anti-human IRF1 Antibody, 25tests","description":"\u003cp\u003eIRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial human IRF1 recombinant protein (147-325 a.a.)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3683350 (BioLegend Cat. No. 332805) AB_3683350 (BioLegend Cat. No. 332806)\u003cbr\u003e\nStructure: 325 amino acids, predicted MW is 37 kD and observed MW is 45 kD. Contains an IRF tryptophan pentad repeat responsible for DNA binding.\u003cbr\u003e\nDistribution: Nucleus\u003cbr\u003e\nFunction: IRF1 is a transcription factor, regulating expression of IFN and IFN-inducible genes. It is also involved in regulating cell proliferation, apoptosis, tumor suppression, and various immune responses.\u003cbr\u003e\nInteraction: Forms homodimers. Interacts with p300, MyD88, and PIAS3.\u003cbr\u003e\nCell Type: Leukocytes, Macrophages, Monocytes, NK cells, T cells, Th1, Tregs\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology, Innate Immunity, Transcription Factors\u003cbr\u003e\nAntigen References: 1. Yarilina A, et al. 2008. Nat. Immunol. 9:378. 2. Kano S, et al. 2008. Nat. Immunol. 9:34.\u003cbr\u003e\nGene ID: 3659\u003cbr\u003e\nUniProt: View information about IRF1 on UniProt.org\u003cbr\u003e\nClone: W17068A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interferon regulatory factor 1 (IRF-1)\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866312167593,"sku":"332805","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-332805","provider":"Iright","version":"1.0","type":"link"}