{"product_id":"biolegend-333801","title":"Biolegend, 333801, Purified anti-human CD68 Antibody, 25μg","description":"\u003cp\u003eCD68 is a 110 kD glycoprotein, also known as macrosialin, belonging to the sialomucin family. It is closely related to the family of acidic, highly glycosylated lysosomal-associated membrane proteins (LAMPs). CD68 is predominately expressed in cytoplasmic granules of monocytes\/macrophages, dendritic cells, and granulocytes. It is one of the useful myeloid cell markers. Further studies have shown that CD68 is also expressed by a subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, and endothelial cells. The biological function of CD68 is still unknown.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality tested ICC - Verified IHC - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported application: immunohistochemical staining of frozen tissue sections. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Doussis IA, et al. 1993. J. Clin. Pathol. 46:334. Davey FR, et al. 1988. J. Clin. Pathol. 41:753. Bushway ME, et al. 2014. Biol Reprod. 90(5): 110. (IF) PubMed\u003cbr\u003e\nProduct Citations: Rajagopalan A, et al. 2021. Cell Rep Methods. 1:. PubMed Aly NAR, et al. 2023. Front Oncol. 12:1009993. PubMed Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed Zhang XN, et al. 2021. Cell Res. . PubMed Carpenter J, et al. 2011. J Virol. 85:9414. PubMed Wei SC et al. 2017. Cell. 170(6):1120-1133 . PubMed Nugent JL, et al. 2021. iScience. 24:103421. PubMed Feng Q, et al. 2017. J Thromb Haemost. 1.90625. PubMed Greven D, et al. 2015. Ann Rheum Dis. 74: 1924 - 1930. PubMed Talbot H, et al. 2020. Sci Rep. 10:12572. PubMed Cole JM, et al. 2021. Cancers (Basel). 13:00. PubMed Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed Trumpi K, et al. 2018. Oncotarget. 3. PubMed Chevrier S, et al. 2018. Cell Syst. 0.675. PubMed Scharenberg SG, et al. 2020. Nat Commun. 2.76875. PubMed Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed\u003cbr\u003e\nRRID: AB_1089059 (BioLegend Cat. No. 333801) AB_1089058 (BioLegend Cat. No. 333802)\u003cbr\u003e\nStructure: Sialomucin family, 110 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells, granulocytes, subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, endothelial cells\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Hematopoietic stem and progenitors, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Holness CL and Simmons DL. 1993. Blood 81:1607. 2. Gottfried E, et al. 2008. Scand. J. Immunol. 67:453. 3. Hameed A, et al. 1994. Hum. Pathol. 25:872.\u003cbr\u003e\nGene ID: 968\u003cbr\u003e\nUniProt: View information about CD68 on UniProt.org\u003cbr\u003e\nClone: Y1\/82A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI MR23\u003cbr\u003e\nOther Names: Macrosialin\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864103243945,"sku":"333801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-333801","provider":"Iright","version":"1.0","type":"link"}