{"product_id":"biolegend-334804","title":"Biolegend, 334804, PE anti-human CD300c Antibody, 100tests","description":"\u003cp\u003eCD300c, also known as CMRF-35-like molecule 6 (CLM-6) and leukocyte immunoglobulin-like receptor (LIR) is a 25 kD protein that belongs to the myeloid-associated immunoglobulin-like receptor (MAIR) family of genes. This transmembrane protein is expressed on certain B cells, T cells, NK cells, granulocytes, macrophages, monocytes, and mast cells. CD300C promotes secretion of proinflammatory cytokines and is an activating immune receptor associated ITAM-bearing adapter DAP12 and FcRγ chain on macrophages.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Simhadri VR, et al. 2013. J. Innate Immun. 4:389.\u003cbr\u003e\nProduct Citations: Cheng WC, et al. 2016. Eur J Immunol. 2211:46. PubMed\u003cbr\u003e\nRRID: AB_2208159 (BioLegend Cat. No. 334804)\u003cbr\u003e\nStructure: Ig superfamily, 40 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells\u003cbr\u003e\nFunction: Regulate myeloid cell activation and promote secretion of cytokines and chemokines\u003cbr\u003e\nInteraction: DAP12, FcRγ\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Borrego F. 2013. Blood 11:1951. 2. Ju X, et al. 2009. Immunobiology 730-736. 3. Simhadri, et al. 2011. BMC Immunology 12:62.\u003cbr\u003e\nGene ID: 10871\u003cbr\u003e\nUniProt: View information about CD300c on UniProt.org\u003cbr\u003e\nClone: TX45\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: LIR, CLM-6, CMRF35, IGSF16, CMRF-35, CMRF35A, CMRF-35A, CMRF35A1, CMRF35-A1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864059662505,"sku":"334804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-334804","provider":"Iright","version":"1.0","type":"link"}