{"product_id":"biolegend-335009","title":"Biolegend, 335009, PE\/Cyanine7 anti-human CD158h (KIR2DS1) Antibody, 25tests","description":"\u003cp\u003eCD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIMs and have activation functions. Fifteen polymorphic KIR genes have been reported in humans. CD158h is a 50 kD, single-pass glycoprotein with two extracellular Ig domains that contains a short cytoplasmic tail and does not contain an intracellular ITIM domain. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DS1 is reported to bind certain HLA-C antigens on target cells (HLA-C*02, HLA-C*04, HLAC*06, for example).\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: KIR2DS1 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Based on in-house testing, clone S22019F does not react to other KIR protein family members.\u003cbr\u003e\nRRID: AB_3717095 (BioLegend Cat. No. 335009) AB_3717095 (BioLegend Cat. No. 335010)\u003cbr\u003e\nStructure: 50 kD two Ig-like extracellular domain glycoprotein\u003cbr\u003e\nDistribution: Subset of NK cells, small subset of T Cells\u003cbr\u003e\nFunction: NK cell regulation\u003cbr\u003e\nLigand\/Receptor: Some HLA-C molecules\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Biassoni, R. et al. 1996. J Exp Med. 183:645-50. Stewart CA, et al. 2005. Proc Natl Acad Sci. 102:13224-9. Lanier, LL. 2005. Annu Rev Immunol. 23:225-74.\u003cbr\u003e\nGene ID: 3806\u003cbr\u003e\nUniProt: View information about CD158h on UniProt.org\u003cbr\u003e\nClone: S22019F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD158H, Killer Cell Immunoglobulin-Like Receptor 2DS1, KIR2DS1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866276909225,"sku":"335009","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-335009","provider":"Iright","version":"1.0","type":"link"}