{"product_id":"biolegend-336434","title":"Biolegend, 336434, Brilliant Violet 510™ anti-human CD61 Antibody, 100tests","description":"\u003cp\u003eCD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41\/CD61 complex and with integrin αV (CD51) to form αV\/β3 (CD51\/CD61) integrin. CD41\/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51\/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human, Cynomolgus, Rhesus\u003cbr\u003e\nReported Reactivity: African Green, Baboon\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 510™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Brilliant Violet 510™ excites at 405 nm and emits at 510 nm. The bandpass filter 510\/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 510™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blotting and immunohistochemical staining of frozen tissue sections.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Davies J, et al. 1989. J. Cell Biol. 109:1817. Roberts M, et al. 2004. Mol. Cell. Biol. 24:1505. Ciarlet M, et al. 2002. J. Virol. 76:1109.\u003cbr\u003e\nRRID: AB_3662233 (BioLegend Cat. No. 336433) AB_3662233 (BioLegend Cat. No. 336434)\u003cbr\u003e\nStructure: Type I integral glycoprotein, integrin family, associates with CD41 (gpIIb) forming CD41\/CD61 complex or with CD51 (integrin αV) forming CD51\/CD61 complex, 90 kD\u003cbr\u003e\nDistribution: CD41\/CD61 complex is expressed on platelets and megakaryocytes; CD51\/CD61 complex is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells\u003cbr\u003e\nFunction: Adhesion, platelet activation and aggregation\u003cbr\u003e\nLigand\/Receptor: Fibronectin, vitronectin, vWF\u003cbr\u003e\nCell Type: Fibroblasts, Megakaryocytes, Osteoclasts, Platelets\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers.\u003cbr\u003e\nGene ID: 3690\u003cbr\u003e\nUniProt: View information about CD61 on UniProt.org\u003cbr\u003e\nClone: VI-PL2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Integrin β3, gpIIIa\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864082829481,"sku":"336434","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-336434","provider":"Iright","version":"1.0","type":"link"}