{"product_id":"biolegend-336906","title":"Biolegend, 336906, PE anti-human CD87 Antibody, 100tests","description":"\u003cp\u003eCD87, known as urokinase plasminogen activator-receptor (uPAR), is a 36-68 kD single-chain glycophosphotidylinositol (GPI)-anchored glycoprotein. The extracellular region of CD87 consists of three homologous domains, D1, D2, and D3. Membrane-bound and soluble (D2D3) forms of uPAR have been reported. The membrane-bound CD87 is expressed on granulocytes, monocytes\/macrophages, dendritic cells, fibroblasts, endothelial cells and keratinocytes. CD87 plays a role in cell adhesion and chemotaxis through binding to β1, β2 and β3 integrins. CD87-bound uPA converts plasminogen to plasmin.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: THP-1 (human myeloid cell line)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications include: VIM5 mAb binds to uPA binding-domain\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Schlossmant SF, et al. eds. 1995 Leukocyte Type V. Oxford University Press Inc, New York Gadd SJ, et al. 1990. Clin. Exp. Immunol 80:252 Sillaber C, et al. 1997. J. Biol. Chem. 272:7824\u003cbr\u003e\nRRID: AB_2165469 (BioLegend Cat. No. 336905) AB_2165468 (BioLegend Cat. No. 336906)\u003cbr\u003e\nStructure: Glycophosphotidylinositol (GPI)-anchored glycoprotein, 36-68 kD\u003cbr\u003e\nDistribution: Granulocytes, monocytes\/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes.\u003cbr\u003e\nFunction: Convert plasminogen to plasmin, cell adhesion, chemotaxis\u003cbr\u003e\nLigand\/Receptor: Urokinase plasminogen activator (uPA), vitronectin, β1, β2 and β3 integrins, kininogen\u003cbr\u003e\nCell Type: Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Beaufort N, et al. 2004. J. Immunol. 172:540 2. Tarui T, et al. 2001. J. Bio. Chem. 276:3983 3. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. A John Wiley \u0026amp; Sons Inc, Publication\u003cbr\u003e\nGene ID: 5329\u003cbr\u003e\nUniProt: View information about CD87 on UniProt.org\u003cbr\u003e\nClone: VIM5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI MR13\u003cbr\u003e\nOther Names: Urokinase plasminogen activator-receptor, uPA-R, uPAR\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864083550377,"sku":"336906","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-336906","provider":"Iright","version":"1.0","type":"link"}