{"product_id":"biolegend-337410","title":"Biolegend, 337410, PE anti-human CD112 (Nectin-2) Antibody, 100tests","description":"\u003cp\u003eCD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembrane glycoprotein, a member of the Ig gene superfamily. It is primarily found on myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34 positive stem cells, endothelial cells, epithelial cells, and neuronal cells. CD112 functions as a receptor for α-herpes viruses HSV-1 and pseudorabies virus (PRV). CD112 is an adhesion molecule involved in the formation of cell junction and regulation of NK- and T cell-mediated cytotoxicity through interaction with CD226 (DNAM-1) and other nectin family molecules.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications include: partially block CD226-Fc binding to CD112 transfectant cells and partially inhibit the cytotoxicity mediated by NK and T cells.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Tahara-Hanaoka S, et al.. 2004. Int. Immunol. 16:533 Lim O, et al. 2013. PLoS One. 8:e53611. PubMed Gillory LA, 2013. PLoS One. 8:77753. PubMed\u003cbr\u003e\nProduct Citations: Korniotis S, et al. 2022. J Cell Sci. 135:. PubMed Gerace D, et al. 2023. Cell Rep Med. 4:100879. PubMed Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed Cordeau M, et al. 2016. PLoS One. 11:e0164401. PubMed Poznanski SM, et al. 2018. Cancer Immunol Res. 1.065277778. PubMed Grandclaudon M, et al. 2019. Cell. 179:432. PubMed Lim O, et al. 2013. PLoS One. 8:e53611. PubMed Gillory L, et al. 2013. PLoS One. 8:77753. PubMed Kaito Y, et al. 2022. Oncol Lett. 23:51. PubMed Suzuki D, et al. 2020. Stem Cell Reports. 14:49. PubMed Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed Siew Y, et al. 2015. Int Immunol. 27: 621 - 632. PubMed\u003cbr\u003e\nRRID: AB_2174163 (BioLegend Cat. No. 337409) AB_2269088 (BioLegend Cat. No. 337410)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, Ig superfamily\u003cbr\u003e\nDistribution: Myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34-positive stem cells, endothelial cells, epithelial cells, and neuronal cells.\u003cbr\u003e\nFunction: Adhesion, receptor for some Herpes Viruses\u003cbr\u003e\nLigand\/Receptor: CD226, CD155, Nectin-1, -3, and -4, Herpes Viruses\u003cbr\u003e\nCell Type: Dendritic cells, Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors, Mast cells, Megakaryocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Zola H et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley \u0026amp; Sons Inc, Publication 2. Bachelet I, et al. 2006. J. Bio. Chem. 281:27190 3. Pende D, et al. 2006. Blood 107:2030 4. Bottino C, et al. 2003. J. Exp. Med. 198:557\u003cbr\u003e\nGene ID: 5819\u003cbr\u003e\nUniProt: View information about CD112 on UniProt.org\u003cbr\u003e\nClone: TX31\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Poliovirus Receptor Related 2 Protein (PRR2), Nectin-2, Hve B\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864058319017,"sku":"337410","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-337410","provider":"Iright","version":"1.0","type":"link"}