{"product_id":"biolegend-337901","title":"Biolegend, 337901, Purified anti-human CD85h (ILT1) Antibody, 25μg","description":"\u003cp\u003eCD85 is a group of Ig superfamily tansmembrane glycoproteins called Ig-Like Transcripts (ILTs) or Leukocyte Immunoglobulin-like Receptors (LIRs). It is composed of both activating and inhibitory isoforms. The activating subset of ILTs is characterized by containing short cytoplasmic domains and positively charged arginine residues, while the inhibitory isoforms display long cytoplasmic tails containing ITIM motifs. CD85h is a 69kD activating receptor, also known as ILT1, LIR-7, or LILRA2. ILT1 is found on the surface of monocytes\/macrophages, dendritic cells, and at relatively low levels on granulocytes. It is also expression on a small subset of NK cells. ILT1 acts as an activating receptor through its association with Fc receptor γ chain.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications include: immunohistochemical staining of acetone-fixed frozen tissue sections, Costimulation and activation of myeloid cells skewing of dendritic cell differentiation\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Lee DJ, et al. 2007 J. Immunol. 179 8128.\u003cbr\u003e\nRRID: AB_1279313 (BioLegend Cat. No. 337902)\u003cbr\u003e\nStructure: ILT\/LIR family, Ig superfamily, 69 kD glycoprotein\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells, granulocytes (low), small subset of NK cells\u003cbr\u003e\nLigand\/Receptor: Associate with Fc receptor γchain\u003cbr\u003e\nCell Type: Dendritic cells, Granulocytes, Macrophages, Monocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Tedla N, et al. 2003. Proc. Natl. Acad. Sci. 100:1174 2. Nakajima H, et al. 1999. J. Immunol. 162:5\u003cbr\u003e\nGene ID: 11027\u003cbr\u003e\nUniProt: View information about CD85h on UniProt.org\u003cbr\u003e\nClone: 24\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ILT1, LIR-7, LILRA2\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860872253609,"sku":"337901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-337901","provider":"Iright","version":"1.0","type":"link"}