{"product_id":"biolegend-338607","title":"Biolegend, 338607, APC anti-human CD132 (common γ chain) Antibody, 25tests","description":"\u003cp\u003eCD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common γ chain (γc), or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK\/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Itano M, et al. 1996. J. Exp. Med. 178:389 Kondo M, et al. 1993. Science 262:1874\u003cbr\u003e\nProduct Citations: Market M, et al. 2022. Int J Mol Sci. 23: . PubMed Wefers C, et al. 2018. Int J Mol Sci. 19. PubMed Rajawat YS, et al. 2021. Hum Gene Ther. 32:113. PubMed Market M, et al. 2020. Front Immunol. 1.127083333. PubMed Kumar A, et al. 2021. STAR Protoc. 2:100874. PubMed Matsubara Y, et al. 2014. Sci Rep. 4:5043. PubMed Massoud R, et al. 2015. Proc Natl Acad Sci U S A. 112: 11030-11035. PubMed Farhat AM, et al. 2021. Cell Reports. 35(4):109044. PubMed Hodge L, et al. 2012. Blood. 120:3774. PubMed Jiang J, et al. 2016. Sci Rep. 6: 32320. PubMed\u003cbr\u003e\nRRID: AB_2123585 (BioLegend Cat. No. 338607) AB_2123584 (BioLegend Cat. No. 338608)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, Ig superfamily 64-70 kD\u003cbr\u003e\nDistribution: T cells, B cells, NK, monocytes, granulocytes\u003cbr\u003e\nLigand\/Receptor: Component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21\u003cbr\u003e\nCell Type: B cells, Granulocytes, Monocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley \u0026amp; Sons Inc, Publication 2. Nakarai T, et al. 1994. J. Exp. Med. 180:241 3. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724 4. Habib T, et al. 2002. Biochemistry. 41:8725 5. Matthews DJ, et al. 1995. Blood 85:38\u003cbr\u003e\nGene ID: 3561\u003cbr\u003e\nUniProt: View information about CD132 on UniProt.org\u003cbr\u003e\nClone: TUGh4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI C-89\u003cbr\u003e\nOther Names: Common γ chain, γc, IL-2 receptor γ subunit\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864052781225,"sku":"338607","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-338607","provider":"Iright","version":"1.0","type":"link"}