{"product_id":"biolegend-339212","title":"Biolegend, 339212, PE\/Cyanine7 anti-human CD328 (Siglec-7) Antibody, 100tests","description":"\u003cp\u003eSiglec-7, also known as p75\/AIRM1, is a 75 kD type I transmembrane protein and a member of the family of sialic acid-binding immunoglobulin-like lectins (Siglecs). It is primarily found on NK cells and monocytes. The cytoplasmic domain of Siglec-7 contains immunoreceptor tyrosine-based inhibitory motif (ITIM). CD328 mediates sialic acid-dependent cell-cell binding and functions as an inhibitory receptor of NK cells. CD328 preferentially binds to sialylated glycans with α2,8 disialyl and α2,6 sialyl residues.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2814247 (BioLegend Cat. No. 339211) AB_2814248 (BioLegend Cat. No. 339212)\u003cbr\u003e\nStructure: Type I transmembrane protein, Siglec family member, 75 kD\u003cbr\u003e\nDistribution: NK cells, monocytes\u003cbr\u003e\nFunction: Inhibitory receptor of NK cells\u003cbr\u003e\nLigand\/Receptor: Sialylated glycans (with α2,8 disialyl and α2,6 sialyl residues)\u003cbr\u003e\nCell Type: Monocytes, NK cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Siglec Molecules\u003cbr\u003e\nAntigen References: Avril T, et al. 2006. Infection and Immunity 74:4133 Avril T, et al. 2004. J. Immunol. 173:6841 Yamaji T, et al. 2005. Glycobiology 15:667\u003cbr\u003e\nGene ID: 27036\u003cbr\u003e\nUniProt: View information about CD328 on UniProt.org\u003cbr\u003e\nClone: 6-434\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VIII 80652\u003cbr\u003e\nOther Names: Siglec7 (Sialic-binding Ig like lectin 7), p75, AIRM1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862464450729,"sku":"339212","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-339212","provider":"Iright","version":"1.0","type":"link"}