{"product_id":"biolegend-340301","title":"Biolegend, 340301, Purified anti-human CD307e (FcRL5) Antibody, 25μg","description":"\u003cp\u003eFcRL5, also known as CD307e, CD307, IRTA2, FcRH5, and BXMAS1, is a 106 kD type I transmembrane glycoprotein composed of six-eight extracellular Ig like C2 domains and two cytoplasmic ITIM motifs. The FcRL5 gene is located on chromosome 1q21 and is normally expressed by tonsillar plasma cells and germinal center B cells. It has been suggested that FcRL5 contributes to B cell maturation and B cell receptor modulation. The identification of FcRL5 on a number of transformed cell types including hairy cell leukemia, mantle cell lymphoma, chronic lymphocytic lymphoma, and Burkitt’s lymphoma has prompted interest in it as a potential biomarker or target for immunotherapy. FcRL5 binds all aggregated IgG isotypes.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: P815 cells transfected with FcRL5\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation and blocking1. mAb 509f6 is able to block the binding of FcRL5 to all aggregated IgG isotypes.1\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Wilson TJ, et al. 2012. J. Immunol. 188:4741. (Block)\u003cbr\u003e\nProduct Citations: McCarthy EE, et al. 2022. Cell Rep. 39:110815. PubMed Obeng-Adjei N, et al. 2017. PLoS Pathog. 13:e1006576. PubMed\u003cbr\u003e\nRRID: AB_2104586 (BioLegend Cat. No. 340302)\u003cbr\u003e\nStructure: 106 kD, Fc receptor like, type 1 transmembrane protein, 6-8 Ig like C2 domains, 2 cytoplasmic ITIM motifs.\u003cbr\u003e\nDistribution: Germinal center B cells, tonsillar plasma cells.\u003cbr\u003e\nLigand\/Receptor: Aggregated IgG\u003cbr\u003e\nCell Type: B cells, Plasma cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Davis R, et al. 2007. Annu. Rev. Immunol. 207:528. 2. Mohan J, et al. 2006. Blood 107:4433. 3. Ise T, et al. 2007. Leukemia. 21:169.\u003cbr\u003e\nGene ID: 83416\u003cbr\u003e\nUniProt: View information about CD307e on UniProt.org\u003cbr\u003e\nClone: 509f6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD307, IRTA2, FcRH5, IFGP5, BXMAS1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862428078249,"sku":"340301","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-340301","provider":"Iright","version":"1.0","type":"link"}