{"product_id":"biolegend-342801","title":"Biolegend, 342801, Alexa Fluor® 647 anti-human CD305 (LAIR1) Antibody, 25tests","description":"\u003cp\u003eCD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm \/ 635nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Poggi A, et al. 1995. Eur. J. Immunol. 25:369\u003cbr\u003e\nProduct Citations: van der Wijst MGP, et al. 2021. Sci Transl Med. 13:eabh2624. PubMed Seery V, et al. 2021. EBioMedicine. 67:103357. PubMed\u003cbr\u003e\nRRID: AB_1659239 (BioLegend Cat. No. 342801) AB_2133480 (BioLegend Cat. No. 342802)\u003cbr\u003e\nStructure: 40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily\u003cbr\u003e\nDistribution: NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells\u003cbr\u003e\nFunction: Inhibition of cell cytotoxicity, cell activation, proliferation and differentiation\u003cbr\u003e\nLigand\/Receptor: collagens\u003cbr\u003e\nCell Type: B cells, Basophils, Dendritic cells, Eosinophils, Macrophages, Mast cells, Monocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Inhibitory Molecules, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Meyaard L, et al. 2008. J. Leukoc. Biol. 83:799 2. Lebbink RJ, et al. 2006. J. Exp. Med. 203:1419\u003cbr\u003e\nGene ID: 3903\u003cbr\u003e\nUniProt: View information about CD305 on UniProt.org\u003cbr\u003e\nClone: NKTA255\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: LAIR-1 (Leukocyte-associated Ig-like receptor 1)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866465063081,"sku":"342801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-342801","provider":"Iright","version":"1.0","type":"link"}