{"product_id":"biolegend-343109","title":"Biolegend, 343109, PE\/Cyanine5 anti-human CD7 Antibody, 25tests","description":"\u003cp\u003eCD7 is a 40 kD type I transmembrane glycoprotein also known as gp40. It is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL) and some acute myeloid leukemia (AML) cells. CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 costimulation can induce cytokine secretion and modulate cellular adhesion.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: KG1a cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE\/Cyanine5.5 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported (for the relevant formats) applications include proteogenomics2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Knapp W, et al. 1989. Leucocyte Typing IV:White Cell Differentiation Antigens. Oxford University Press. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)\u003cbr\u003e\nProduct Citations: Houlder E, et al. 2023. Nat Commun. 14:1863. PubMed Jung J, et al. 2019. Cell Rep. 26:1906. PubMed Bill M, et al. 2018. J Cell Mol Med. 22:2311. PubMed Rodriguez‐Meira A et al. 2019. Molecular cell. 73(6):1292-1305 . PubMed\u003cbr\u003e\nRRID: AB_2075096 (BioLegend Cat. No. 343110)\u003cbr\u003e\nStructure: Ig superfamily, type I transmembrane glycoprotein, 40 kD\u003cbr\u003e\nDistribution: T cells, NK cells, thymocytes, hematopoietic progenitors, myeloid leukemic cell subsets\u003cbr\u003e\nFunction: T cell activation\u003cbr\u003e\nLigand\/Receptor: Cytoplasmic domain associates with P13-kinase\u003cbr\u003e\nCell Type: Hematopoietic stem and progenitors, Leukemia, NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego. 2. Stillwell R, et al. 2001. Immunol. Res. 24:31. 3. Rabinowich H, et al. 1994. J. Immunol. 152:517.\u003cbr\u003e\nGene ID: 924\u003cbr\u003e\nUniProt: View information about CD7 on UniProt.org\u003cbr\u003e\nClone: CD7-6B7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: IV T-164\u003cbr\u003e\nOther Names: gp40\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862988279977,"sku":"343109","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-343109","provider":"Iright","version":"1.0","type":"link"}