{"product_id":"biolegend-343302","title":"Biolegend, 343302, Purified anti-human HLA-A2 Antibody, 100μg","description":"\u003cp\u003eHLA-A2 is most common in Northern Asia and North America populations. MHC class I antigens associated with β2-microglobulin are expressed by all human nucleated cells. MHC class I molecules are involved in presentation of antigens to CD8 + T cells, playing an important role in cell-mediated immune responses and tumor surveillance.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Papain solubilized HLA-A2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The BB7.2 antibody recognizes human leukocyte antigen (HLA) A2 which is a subset of MHC-class I molecules encoded by A*02 alleles. Additional reported applications (for the relevant formats) include: immunoprecipitation3.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Brodsky FM, et al. 1979. Immunol. Rev. 47:3. Parham P and Brodsky FM. et al. 1981. Hum. Immunol. 3:277. Lubben NB, et al. 2007. Mol Biol Cell. 18:3351. (IP)\u003cbr\u003e\nProduct Citations: Chou JM, et al. 2022. Front Microbiol. 13:883597. PubMed Willimsky G, et al. 2021. Elife. 10:. PubMed Jensen SM, et al. 2018. Front Immunol. 9:2697. PubMed Reithofer M, et al. 2020. Eur J Immunol. 51:721. PubMed Chheda ZS, et al. 2018. J Exp Med. 9:19490. PubMed Song S, et al. 2021. Front Immunol. 12:705140. PubMed Matsuoka K, et al. 2022. J Biol Chem. :101724. PubMed\u003cbr\u003e\nRRID: AB_1659243 (BioLegend Cat. No. 343302)\u003cbr\u003e\nStructure: Ig superfamily\u003cbr\u003e\nDistribution: A*02 individuals leukocytes\u003cbr\u003e\nFunction: Antigen presentation\u003cbr\u003e\nLigand\/Receptor: CD8, CD3\/TCR\u003cbr\u003e\nCell Type: Leukocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nGene ID: 3105\u003cbr\u003e\nUniProt: View information about HLA-A2 on UniProt.org\u003cbr\u003e\nClone: BB7.2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MHC-class I\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862902001833,"sku":"343302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-343302","provider":"Iright","version":"1.0","type":"link"}