{"product_id":"biolegend-349302","title":"Biolegend, 349302, Purified anti-human TCR Vβ5 Antibody, 100μg","description":"\u003cp\u003eVβ5 T cell receptor (TCR Vβ5) is a variant of the TCR β chain which is heterodimerized with TCR α chain and expressed on a subset of αβ + T cells. TCR α\/β recognizes peptides presented by the MHC molecules and initiates T cell mediated immune responses. Patients with multiple sclerosis present an  expansion of Vβ5.2 + \/5.3 + autoreactive T cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Pigtailed Macaque\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Labrecque N, et al. 1993. J. Exp. Med. 177:1735. (FC) Oh S, et al. 2004. Cancer Res. 64:2610. (FC) Wilson JDK, et al. 1998. Eur. J. Immunol. 28:1172. (FC) Patel MR, et al. 2010. Cancer Res. 70:10141. PubMed Han JA, et al. 2014. Nanomedicine. 10:561. PubMed\u003cbr\u003e\nProduct Citations: Patel M, et al. 2010. Cancer Res. 70:10141. PubMed Li F, et al. 2022. Nat Commun. 13:4334. PubMed Han J, et al. 2014. Nanomedicine. 10:561. PubMed\u003cbr\u003e\nRRID: AB_10643416 (BioLegend Cat. No. 349301)\u003cbr\u003e\nStructure: Immunoglobulin superfamily, associates with TCR Vα chain and CD3 complex\u003cbr\u003e\nDistribution: Subset of TCR αβ+ T cells\u003cbr\u003e\nFunction: Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune response\u003cbr\u003e\nLigand\/Receptor: MHC-peptide complex\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: 1. Kuchroo VK, et al. 2002. Annu. Rev. Immunol. 20:101. 2. Venturi V, et al. 2008. Nat. Rev. Immunol. 8:231. 3. Matsumoto Y, et al. 2003. J. Immunol. 170:4846. 4. Killestein J, et al. 2002. Ann. Neurol. 51:467.\u003cbr\u003e\nGene ID: 6957\u003cbr\u003e\nUniProt: View information about TCR Vbeta5 on UniProt.org\u003cbr\u003e\nClone: MH3-2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell receptor V beta 5\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866127487145,"sku":"349302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-349302","provider":"Iright","version":"1.0","type":"link"}