{"product_id":"biolegend-350011","title":"Biolegend, 350011, PE\/Cyanine7 anti-human CD134 (OX40) Antibody, 25tests","description":"\u003cp\u003eCD134, also known as OX40 and TNFRSF4, is a 50 kD type I transmembrane glycoprotein. It is a member of the TNF receptor family. OX40 is expressed on activated T lymphocytes including Th1, Th2, Th17, and Treg cells. The interaction of OX40 with OX40L results in B cell proliferation and antibody secretion, regulation of primary T cell expansion, and T cell survival. OX40 influences the size of the T cell memory pool and regulation of CD4 + T cell tolerance.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Chimpanzee\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: HTLV 1-transformed HUT 102 cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, immunohistochemical staining2,3of paraffin embedded7 and frozen tissue sections, ELISA4, and functional assay5. The LEAF™ or Ultra-LEAF™ purified antibody is recommended for functional assays (contact our custom solutions team).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Latza U, et al. 1994. Eur. J. Immunol. 24:677. (WB, IP) Durkop H, et al. 1995. Brit. J. Haematol. 91:927. (IHC) Durkop H, et al. 1997. Brit. J. Haematol. 98:863. (IHC) Willett B, et al. 2007. J. Virol. 81:9665. (ELISA) Li M and Zhang Y. et al. 2005. Cell. Mol. Immunol. 2:467. (FA) Gloviczki ML, et al. 2012. Clin. J. Am. Soc. Nephrol. 8:546. PubMed Domingos PL, et al. 2012. An. Bras. Dermatol. 87:851. (IHC)\u003cbr\u003e\nProduct Citations: Tarke A, et al. 2021. Cell Reports Medicine. 2(2):100204. PubMed Sun P, et al. 2022. iScience. 25:105202. PubMed Fendler A, et al. 2022. Cell Rep Med. 3:100781. PubMed Ainsua-Enrich E, et al. 2022. iScience. 25:105455. PubMed Ryan FJ, et al. 2023. Cell Rep Med. 4:100971. PubMed Tarke A, et al. 2023. Cell Rep Med. 4:101088. PubMed Apostolidis SA, et al. 2021. Nat Med. 27:1990. PubMed Arce Vargas F et al. 2018. Cancer cell. 33(4):649-663 . PubMed Tarke A, et al. 2021. Cell Reports Medicine. 2(7):100355. PubMed Kuo HH, et al. 2018. Immunity. 48:1183. PubMed Painter MM, et al. 2021. Immunity. 54:2133. PubMed Grifoni A, et al. 2020. Cell. 181(7):1489-1501.e15.. PubMed Tarke A, et al. 2022. Cell. 185:847. PubMed Zhang J, et al. 2020. Nat Microbiol. . PubMed Chellappa S, et al. 2016. J Leukoc Biol. 100: 5 - 16. PubMed Colineau L, et al. 2015. PLoS One. 10: e0140978. PubMed Voic H, et al. 2020. J Virol. 94: . PubMed Peluso MJ, et al. 2021. Cell Rep. 36:109518. PubMed Yu ED, et al. 2022. Cell Host Microbe. 30:1269. PubMed Dan J, et al. 2016. J Immunol. 197: 983 - 993. PubMed Tarke A, et al. 2022. Int J Mol Sci. 23:. PubMed Bradley D, et al. 2022. Nat Commun. 13:5606. PubMed Lederer K, et al. 2022. Cell. . PubMed Schouest B, et al. 2021. J Virol. 95:. PubMed Franchini DM et al. 2019. Cell reports. 26(1):94-107 . PubMed Yu ED, et al. 2022. Cell Host Microbe. . PubMed\u003cbr\u003e\nRRID: AB_10901161 (BioLegend Cat. No. 350012)\u003cbr\u003e\nStructure: 50 kD, TNF receptor family\u003cbr\u003e\nDistribution: Activated T cells\u003cbr\u003e\nFunction: Receptor for OX40 ligand, co-stimulatory signal for T cell proliferation and survival.\u003cbr\u003e\nLigand\/Receptor: OX40L (CD252)\u003cbr\u003e\nCell Type: T cells, Tregs\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: 1. Smith CA, et al. 1994. Cell. 76:959. 2. Chen AL, et al. 1999. Immunity. 11:689. 3. Croft M. 2010. Annu. Rev. Immunol. 28:57. 4. Withers DR, et al. 2009. J. Immunol. 183:5079. 5. Klinger M, et al. 2009. J. Immunol. 182:4581.\u003cbr\u003e\nGene ID: 7293\u003cbr\u003e\nUniProt: View information about CD134 on UniProt.org\u003cbr\u003e\nClone: Ber-ACT35 (ACT35)\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ACT35 antigen, tumor necrosis factor receptor superfamily member 4 (TNFRSF4)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862905868457,"sku":"350011","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-350011","provider":"Iright","version":"1.0","type":"link"}