{"product_id":"biolegend-352601","title":"Biolegend, 352601, Purified anti-human CD220 Antibody, 25μg","description":"\u003cp\u003eCD220, also known as insulin receptor, is a type I transmembrane receptor tyrosine kinase composed of two extracellular α-subunits and two transmembrane β-subunits. Binding insulin, the insulin receptor forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor.  Activation of insulin receptor leads to subsequent downstream signaling in metabolic regulation, inducing glucose uptake, cell growth, differentiation, and apoptosis. Gene mutation in the insulin receptor or decreased insulin receptor signaling leads to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus (diabetes mellitus type 2). Most normal cells constitutively express insulin receptors. In hematopoietic cells, insulin receptor is constitutively expressed on monocytes and selectively expressed on activated lymphocytes.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human insulin receptor\/freund's adjuvant\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Wroblewska A et al. 2018. Cell. 175(4):1141-1155 . PubMed Müller M, et al. 2021. Nat Commun. 12:7036. PubMed\u003cbr\u003e\nRRID: AB_10896052 (BioLegend Cat. No. 352602)\u003cbr\u003e\nStructure: Consist of two alpha subunits and two beta subunits; the beta subunit passes through the cellular membrane and is linked by disulfide bonds.\u003cbr\u003e\nDistribution: Hematopoietic and non hematopoietic cells.\u003cbr\u003e\nFunction: Regulates cell metabolism and growth.\u003cbr\u003e\nInteraction: Ectonucleotide pyrophosphatase\/phosphodiesterase, PTPN11, GRB10, GRB7, PRKCD, IRS1, SH2B1 and Mothers against decapentaplegic homolog 2.\u003cbr\u003e\nLigand\/Receptor: Insulin\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Protein Synthesis, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules, Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: 1. Viardot A, et al. 2006. Endocrinology 148:346. 2. Ward CW, et al. 2009. Bioessays 31:422. 3. Brindle NP, et al. 1990. Biochem. J. 268:615.\u003cbr\u003e\nGene ID: 3643\u003cbr\u003e\nUniProt: View information about CD220 on UniProt.org\u003cbr\u003e\nClone: B6.220\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Insulin Receptor\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862895022249,"sku":"352601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-352601","provider":"Iright","version":"1.0","type":"link"}