{"product_id":"biolegend-353603","title":"Biolegend, 353603, PE anti-human CD371 (CLEC12A) Antibody, 25tests","description":"\u003cp\u003eCD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family.  It is expressed on monocytes, granulocytes, NK cells, and basophils.  Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: 293T cells expressing CLEC12A-Flag\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Lahoud MH, et al. 2009. J. Immunol. 182:7587. (FC) Lahoud MH, et al. 2011. J. Immunol. 187:842. (FC) Neumann K, et al. 2014. Immunity. 40:389. PubMed\u003cbr\u003e\nProduct Citations: Wu CY, et al. 2020. J Immunol. 205:1513. PubMed Arvindam US, et al. 2021. Leukemia. 35:1586. PubMed Lin G, et al. 2021. Mol Med Rep. 23:. PubMed\u003cbr\u003e\nRRID: AB_11125356 (BioLegend Cat. No. 353603) AB_11126169 (BioLegend Cat. No. 353604)\u003cbr\u003e\nStructure: Type II C-type lectin family member, 265 aa, 30.7 kD\u003cbr\u003e\nDistribution: Monocytes, granulocytes, NK cells, and basophils\u003cbr\u003e\nFunction: Negative regulator of granulocyte and monocyte function\u003cbr\u003e\nInteraction: PTPN6 and PTPN11\u003cbr\u003e\nCell Type: Basophils, Dendritic cells, Granulocytes, Monocytes, NK cells\u003cbr\u003e\nBiology Area: Immunology, Costimulatory Molecules\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Lahoud MH, et al. 2009. J. Immunol. 182:7587. 2. Chen CH, et al. 2006. Blood 107:1459. 3. Marshall AS, et al. 2004. J. Biol. Chem. 279:14792.\u003cbr\u003e\nGene ID: 160364\u003cbr\u003e\nUniProt: View information about CD371 on UniProt.org\u003cbr\u003e\nClone: 50C1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862428438697,"sku":"353603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-353603","provider":"Iright","version":"1.0","type":"link"}