{"product_id":"biolegend-353904","title":"Biolegend, 353904, PE anti-human CD365 (Tim-1) Antibody, 100tests","description":"\u003cp\u003eCD365 (Tim-1) is a transmembrane glycoprotein expressed on activated CD4 + lymphocytes especially on Th2 cells. It has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is a hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in the costimulation of T cell proliferation. Tim-1 has been reported to be an endogenous ligand for LMIR5 (Leukocyte mono-immunoglobulin (Ig)-like receptor 5), and the Tim-1-LMIR5 interaction plays a physiological role in immune regulation by myeloid cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human TIM-1-IgV Fc\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported application (for the relevant formats) include: blocking function1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Freeman GJ, et al. 2007. Immunity. 27:927. (Block)\u003cbr\u003e\nProduct Citations: Lin JR et al. 2018. eLife. 7 pii: e31657. PubMed Aravena O, et al. 2017. Arthritis Res Ther. 19:8. PubMed Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed Smith CM, et al. 2021. Biochem J. 478:3331. PubMed\u003cbr\u003e\nRRID: AB_11125165 (BioLegend Cat. No. 353903) AB_11125175 (BioLegend Cat. No. 353904)\u003cbr\u003e\nStructure: Type 1 transmembrane glycoprotein.\u003cbr\u003e\nDistribution: Activated CD4+ lymphocytes, especially on Th2 cells.\u003cbr\u003e\nFunction: TIM-1 ligation induces T cell proliferation, promotes cytokine production, and aids in the regulation of Th2 immunity.\u003cbr\u003e\nLigand\/Receptor: TIM-4\u003cbr\u003e\nCell Type: Dendritic cells, T cells, Th2\u003cbr\u003e\nBiology Area: Immunology, Inhibitory Molecules\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Freeman GJ, et al. 2007. Immunity. 27:927. 2. Meyers JH, et al. 2005. Nat. Immunol. 6:455. 3. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454. 4. Mariat C, et al. 2005. Philos. Trans. R. Soc. Lond. B. 360:1681. 5. Yamanishi Y, et al. 2010. J. Exp. Med. 207:1501.\u003cbr\u003e\nGene ID: 26762\u003cbr\u003e\nUniProt: View information about CD365 on UniProt.org\u003cbr\u003e\nClone: 1D12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: T cell immunoglobulin mucin 1, TIMD-1, KIM-1 (kidney injury molecule-1), HAVCR-1, CD365\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860850659497,"sku":"353904","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-353904","provider":"Iright","version":"1.0","type":"link"}