{"product_id":"biolegend-354604","title":"Biolegend, 354604, PE anti-human CD290 (TLR10) Antibody, 100tests","description":"\u003cp\u003eCD290, also known as TLR10, is a 91-100 kD glycosylated protein belonging to the toll-like receptor family. It is expressed on B cell, Treg cells, and plasmacytoid dendritic cells but absent on T cells, particularly non-Treg and granulocytes. It can interact with MyD88 and plays an important role in innate immunity and pattern recognition.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified extracellular domain of human TLR10 (amino acids 20-474) (NP_001017388 )\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Guan Y, et al. 2010. J. Immunol. 184:5094.\u003cbr\u003e\nRRID: AB_11219598 (BioLegend Cat. No. 354603) AB_11219791 (BioLegend Cat. No. 354604)\u003cbr\u003e\nStructure: Member of the toll-like receptor family, type I membrane protein, 91-100 kD\u003cbr\u003e\nDistribution: B cells, Treg cells, plasmacytoid DCs\u003cbr\u003e\nFunction: Interacts with MyD88 and TRAF6, which results in NF-kB activation and cytokine secretion\u003cbr\u003e\nLigand\/Receptor: MyD88 and TRAF6\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Tregs\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Toll Like Receptors\u003cbr\u003e\nAntigen References: 1. Chuang T, et al. 2001. Biochim. Biophys. Acta. 1518:157. 2. Hornung V, et al. 2002. J. Immunol. 168:4531. 3. Bourke E, et al. 2003. Blood 102:956.\u003cbr\u003e\nGene ID: 81793\u003cbr\u003e\nUniProt: View information about CD290 on UniProt.org\u003cbr\u003e\nClone: 3C10C5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Toll like receptor 10\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862389149865,"sku":"354604","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-354604","provider":"Iright","version":"1.0","type":"link"}