{"product_id":"biolegend-354908","title":"Biolegend, 354908, PerCP\/Cyanine5.5 anti-human CD21 Antibody, 100tests","description":"\u003cp\u003eCD21 is a 145 kD transmembrane protein also known as complement C3d receptor (C3dR), complement receptor 2 (CR2), and Epstein-Barr virus receptor. CD21 is expressed on B cells, follicular dendritic cells, subsets of normal thymocytes and T cells, and some epithelial cells. CD21 is the receptor used by Epstein-Barr virus to infect B cells and is also the complement receptor for C3d. CD21 has also been shown to interact with a number of proteins, including CD23, CD19, annexin VI, CD81, iC3b, complement receptor 1 (CR1, CD35), and interferon-alpha 1 (IFN-α1).\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PerCP\/Cyanine5.5 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * PerCP\/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections4.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Björck P, et al. 1993. Eur. J. Immunol. 23:1771. Frémeaux-Bacchi V, et al. 1996. Eur. J. Immunol. 26:1497. Ling NR, et al. 1995. Clin. Exp. Immunol. 101:369. Wang, C, et al. 2011. BMC Immunol. 12:53. (IHC)\u003cbr\u003e\nProduct Citations: Xu Q, et al. 2023. Nat Immunol. 24:186. PubMed Wentink M, et al. 2015. Clin Immunol. Available online 30 August 2015. PubMed Zumaquero E, et al. 2019. Elife. 8. PubMed Johnson P, et al. 2015. Clin Cancer Res. 21:1321. PubMed Fu Y, et al. 2021. Cell Reports. 36(2):109344. PubMed\u003cbr\u003e\nRRID: AB_2561543 (BioLegend Cat. No. 354907) AB_2561544 (BioLegend Cat. No. 354908)\u003cbr\u003e\nStructure: Transmembrane protein, multiple SUSHI domains, approximate molecular weight 145 kD\u003cbr\u003e\nDistribution: Expressed on B cells, follicular dendritic cells, subsets of normal thymocytes and T cells, some epithelial cells\u003cbr\u003e\nFunction: Epstein-Barr virus receptor on B cells used for infection\u003cbr\u003e\nInteraction: CD23, CD19, complement component 3, annexin VI, CD81, iC3b, complement receptor 1, interferon alpha 1\u003cbr\u003e\nLigand\/Receptor: C3d, EBV\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Epithelial cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Cell Biology, Complement, Costimulatory Molecules, Immunology, Innate Immunity, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Kishimoto T, Eds. 1997. Leukocyte Typing VI. Garland Publishing Inc. 2. Moore MD, et al. 1987. Proc. Natl. Acad. Sci. USA 84:9194. 3. Szakonyi G, et al. 2001. Science 292:1725. 4. Weis JJ, et al. 1984. Proc. Natl. Acad. Sci. USA 81:881.\u003cbr\u003e\nGene ID: 1380\u003cbr\u003e\nUniProt: View information about CD21 on UniProt.org\u003cbr\u003e\nClone: Bu32\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V CD21.4, VI CD21.5\u003cbr\u003e\nOther Names: Complement C3d receptor (C3dR), complement receptor 2 (CR2), Epstein-Barr virus receptor\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: How stable is PerCP\/Cyanine5.5 tandem as compared to PerCP alone?\u003cbr\u003e\nA: PerCP\/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862921629865,"sku":"354908","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-354908","provider":"Iright","version":"1.0","type":"link"}