{"product_id":"biolegend-357804","title":"Biolegend, 357804, PE anti-human ROR1 Antibody, 100tests","description":"\u003cp\u003eROR1, also known as NTRKR1, is a type I transmembrane protein and member of the ROR subfamily of surface receptors. ROR1 consists of one frizzled domain, one Ig-like C2-type domain, one kringle domain, and one kinase domain with no catalytic activity. ROR1 is expressed on embryonic tissue, in the central nervous system and on some cancer cells, and is used as a marker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand for ROR1.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone 2A2 binds to the membrane distal Ig-domain of ROR1. Clone 2A2 has also been shown to exhibit cross reactivity towards mouse ROR12.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Dave H, et al. 2012. PLoS One 7:e52655. (FC) Baskar S, et al. 2012. MAbs. 4:349. (FC)\u003cbr\u003e\nProduct Citations: Hu EY, et al. 2021. Blood Adv. 5:3152. PubMed Huang X, et al. 2015. PLoS One. 10: 0133152. PubMed\u003cbr\u003e\nRRID: AB_2561988 (BioLegend Cat. No. 357803) AB_2561989 (BioLegend Cat. No. 357804)\u003cbr\u003e\nStructure: Type I transmembrane protein, consist of 1 frizzled domain, 1 Ig-like C2-type domain, 1 kringle domain, and 1 non-functional kinase domain; member of the ROR subfamily of surface receptors\u003cbr\u003e\nDistribution: Embryonic tissue, central nervous system, chronic lymphocytic leukemia cells\u003cbr\u003e\nLigand\/Receptor: Wnt5a\u003cbr\u003e\nCell Type: Embryonic Stem Cells, Leukemia\u003cbr\u003e\nBiology Area: Immunology, Stem Cells\u003cbr\u003e\nAntigen References: Bicocca VT, et al. 2012. Cancer Cell. 22:656. Zhang S, et al. 2012. PLoS One 7:e31127. Uhrmacher S, et al. 2011. Leuk Res. 35:1360. Yang J, et al. 2011. PLoS One 6:e21018. Grumolato L, et al. 2010. Genes Dev. 24:2517.\u003cbr\u003e\nGene ID: 4919\u003cbr\u003e\nUniProt: View information about ROR1 on UniProt.org\u003cbr\u003e\nClone: 2A2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Receptor tyrosine kinase-like orphan receptor 1, Tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase receptor-related 1, NTRKR1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866550980777,"sku":"357804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-357804","provider":"Iright","version":"1.0","type":"link"}